Custom Antibody Development Services

Customized Solutions for Antibody Development and Production

R&D Systems produces specific and consistent antibodies with over three decades of industry leadership. Leverage our experience to fast track your next custom antibody project.  With over 20,000 antibody products validated in 25+ species and 15+ applications, our services will fit into your work flow.

We develop a custom project plan specifically tailored to fit your needs. Your personal custom project plan will incorporate the unique challenges of your target and application, there is no cookie cutter approach for our custom projects! Get to large scale custom antibody production quicker, Use our existing experience with challenging targets and application screening at early stages of antibody development.

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Customized Antibody Services Antibody Development and Antibody Production

About Our Antibody Development Workflows

Host Species

R&D Systems offers custom antibody development in many host species. The most common species include mouse, rat, rabbit, goat, sheep, chicken, and llama (camelid). Select your host species upon the goals of your project or ask us to recommend a host for antibody production based upon your target and your application.

Tailored Protocols

We will target custom antibodies with high specificity and outstanding performance for your desired application by coupling a bespoke immunization and screening protocol with one of our immunogen options; full length, biologically active proteins, transfected cells, or target specific peptides.

Quality Oversight

R&D Systems' custom projects are governed under our existing quality management system. Each antibody is developed to your specifications then manufactured under controlled conditions, undergoing rigorous quality control testing to ensure lot-to-lot consistency and outstanding performance in all validated applications.

Common Applications

ELISA Matched Antibody Pairs
ELISA Matched Antibody Pairs

Our optimized protocols and extensive antibody screening capabilities, combined with the powerful expertise behind our gold-standard Quantikine ELISA kits, offers you the best chance at finding the ideal pair for your platform. We will use existing screening techniques to quickly find a pair that will work for you.

Blocking/Neutralization Antibodies

Our extensive collection of bioactive proteins and broad portfolio of existing bioassay SOPs allow us to quickly modify our methods for early screening and identification of neutralizing or blocking custom antibodies. This allows us to provide the best and most dependable blocking/neutralizing antibodies for your project.

IHC/ICC Antibodies

Utilize our proficiency in generating best in class IHC/ICC antibodies; we have produced >4,000! If your goal is to obtain highly specific custom antibodies for IHC or ICC, depend upon us to tailor our immunization and screening protocols to quickly identify clones ideal for your sample.

Flow Cytometry Antibodies
Flow Cytometry

Deploy our rigorous custom antibody protocols, which include early screening, to get your custom flow cytometry antibody quicker! We provide unconjugated or conjugated antibodies that fit into your cell selection and detection workflow with many fluorophores immediately available for custom antibody conjugation

Custom Monoclonal Antibody Production

Custom Monoclonal Antibody Production

At R&D Systems, we’ve generated more than 15,000 hybridomas for our catalog. We can generate up to 40 hybridomas per fusion which gives you flexibility to find the clone that actually works in your application. Our custom monoclonal antibody production process includes:

  • Immunize, boost, and harvest spleen
  • Fusion (two mice per fusion)
  • Subcloning (multiple rounds, screening tens of thousands of clones)
  • Pilot lot grow up
  • Purification
  • QC Testing

Custom Polyclonal Antibody Production

Custom Polyclonal Antibody Production

Using a defined immunization, boost and bleed schedule, and purification methods, we develop highly specific polyclonal antibodies for your application. We offer polyclonal development in llamas, goats, sheep, or rabbits and can convert to recombinant monoclonal antibodies if the need arises to secure long term supply. Our custom polyclonal antibody process includes:

  • Immunize, boost, and test bleed
  • Production bleeds
  • Serum pooling
  • Purification
  • QC Testing

Custom Llama (Camelid) and Recombinant Monoclonal Antibody Production

Custom Llama (Camelid) and Recombinant Monoclonal Antibody Production

Using tested and verified models with B cell isolation from blood we can quickly generate recombinant monoclonal antibodies and perform early screening in your application. We have a demonstrated track record of success with robust antibody engineering and expression platforms providing flexibility and long-term supply.

Our custom rabbit recombinant monoclonal antibody production process includes:

  • Immunization, boosting, and test bleed
  • Production bleeds
  • B cell isolation
  • Transfection into proprietary vector
  • Purification
  • QC Testing

Our custom llama, heavy chain, recombinant monoclonal antibody (HCAB) production process, includes the same as for rabbit plus:

  • B-cell panning expertise for diverse immune libraires
  • Options for many HCAB formats, Llama IgG, Human IgG and Nanobodies, with VHH only or VHH multimers