The Language of Immunology
Do you know the function of more than ten CD markers? Do you know all the steps in the complement pathway? Do you have a favorite T cell?
If you answered yes to any of these questions, you must be an immunologist!
Immunology is a dynamic and complex science that we can help you navigate. While the language of immunology can be confusing, R&D Systems reagents are designed and manufactured to streamline your research and help you achieve success on your own terms. Our reagents are defined by consistency, specificity, and precision. Come explore immunology products and resources at R&D Systems.
Featured Research Areas
Toll-like Receptors
TLRs detect pathogen- or damage-associated molecules and initiate immune responses. Learn more about TLR signaling.
NOD-like Receptors & Inflammasomes
Inflammasomes trigger inflammatory responses following pathogen detection. Discover more about NLRs and inflammasomes.
Immune Cell Therapy
Seamlessly transition the development of immune cell therapies from research to the clinic with our solutions for cell therapy.
Immunology Research by Cell Type
The immune system consists of a variety of different immune cell types and cell type-specific subsets that work together to protect the host against invading pathogens and restore tissue homeostasis. Explore the sections below to find tools for the culture and analysis of different immune cell types.
Dendritic Cells
Dendritic cells regulate T cell activation and promote the differentiation of effector T cell subsets. Learn about different DC subsets.
Monocytes
Monocytes migrate to sites of inflammation and differentiate into macrophages or MoDCs. Discover more about monocyte functions.
Macrophages
Macrophages protect against invading pathogens and maintain tissue homeostasis. Explore macrophage phenotypes and functions.
Natural Killer Cells
NK cells have cytotoxic potential and cytokine-producing capabilities. Learn more about NK cell activation and markers.
CD4+ T Cells
CD4+ T cells play a central role in regulating adaptive immune responses. Discover more about T cell culture and analysis.
B Cells
B cells produce antibodies against foreign antigens and generate immunological memory. Read more about B cell culture and analysis.
Immunology Research by Signaling Pathways
Immune responses to invading pathogens are tightly regulated by intracellular signaling pathways that control immune cell activation, proliferation, and migration, the expression and secretion of pro-inflammatory mediators, and the restoration of tissue homeostasis. Explore the sections below to learn about the different cytokine signaling pathways that are involved in regulating immune cell activities and directing immune responses.
Chemokines
Chemokines regulate immune cell migration under homeostatic and inflammatory conditions. Learn about chemokine subfamilies and functions.
Common Receptor Gamma Chain Family
Common receptor gamma chain cytokines regulate the development and functions of immune cells. Read more about common gamma chain family cytokines.
IL-1 Family Cytokines
IL-1 family cytokines have pro- and anti- inflammatory effects. Learn more about IL-1 family cytokines and signaling pathways.
IL-6 Family Cytokines
IL-6 family cytokines have both unique and overlapping functions on hematopoietic cells. Explore the functions of IL-6 family cytokines.
Interferons
Interferons have anti-viral and immune regulatory effects. Discover the signaling pathways activated by type I,
type II, and type III IFNs.
TNF Superfamily
TNF superfamily proteins regulate the functions of innate and adaptive immune cells. Learn more about the TNF superfamily.
Key Products for Immunology Research
Cytokines for Immune Cell Culture
Optimize your immune cell cultures with R&D Systems proteins. Our proteins provide exceptional performance and lot-to-lot consistency so you can limit variability from one experiment to the next. From basic research to clinical applications, we offer research-grade, Animal-free Preclinical, and GMP-grade cytokines to meet all experimental needs.
Biotinylated Immune Checkpoint Proteins
Develop a highly sensitive inhibitor screening assay with our wide selection of biotinylated immune checkpoint proteins. Our proteins will provide the performance and consistency you need to advance your drug discovery research.
ELISA Kits
Utilize our rigorously validated ELISA Kits to get the sensitivity and precision needed for accurate, reproducible data every time.
Blocking/Neutralizing Antibodies
Investigate protein functions using our collection of over 1,400 blocking/neutralizing antibodies, which includes cytokine, chemokine, and immune checkpoint blocking antibodies. These antibodies are validated using the same bioassays we use to test the bioactivity of our proteins, ensuring they block/neutralize the appropriate cellular function.
Antibodies for Flow Cytometry
Discover our expansive portfolio of primary antibodies conjugated to one of over 30 fluorescent labels. This selection allows direct detection of cell surface and intracellular targets with the highest level of flexibility for multiplex experiments.
Luminex® Assays
Multiplex up to 50 analytes and conserve on sample, time, and cost. Luminex assays provide reliable, reproducible data because every panel is QC tested.
Immunology Resources
Discover the latest resources to help advance your immunology research. From protocols and how-to guides to webinars and posters, our resources are intended to share knowledge and serve as reliable reference tools.
Periodic Table of Cytokine Families Poster
We love to make and measure cytokines and put them together in interesting ways. Check out our latest poster, it’s sure to brighten up your lab.
ELISA Guide
Explore our comprehensive guide to running a successful ELISA, including different formats, best practices, controls, and troubleshooting.
App Note: Development of an IL-2 Heat Stable Agonist Protein
Discover the benefits of IL-2 Heat Stable Agonist Protein, which can withstand high temperatures and extended culture durations.
Application Notes
Avoid False Positive Data: Improve Performance with R&D Systems™ Quantikine™ Assays
A Simple Flow Cytometry-Based Assay for Detecting CAR Expression Using Fluorokines™
Multi-Color Flow Cytometry Panels for Immunophenotyping of Expanded T Cells (Bio-Techne)
Immunology Protocols
