Generate custom monoclonal or polyclonal antibodies from scratch. We will work with you from immunogen design through purification and QC to ensure antibody specificity and long term supply. Partner with our expert development team.
Recombinant Antibody and Antibody Engineering
Develop a new recombinant antibody or enhance your existing clones. Add engineering services to solve unique technical challenges.
What to Expect
High Performance Products
R&D Systems is known for its quality products, lot to lot consistency, and long-term supply. You can expect the same for your customized antibody reagents. We will provide the highly specific antibodies you need to move your project forward!
Access To Scientists
Our custom reagents are developed by the same scientists that make the retail products you trust. Utilize their decades of experience from project design to delivery. With full length, active immunogens and optimized protocols tailored to your project, we will ensure your specifications are met.
Customized Reagents and Testing
With unique engineering solutions, we can tailor your reagent to meet the requirements of your application. Using our existing protocols, we can provide you the optimal reagent on your timeline.
All our custom antibody services are governed by established, rigorous quality assurance measures, so you can be confident in the accuracy of the data and the performance of your custom product.
At R&D Systems, we have been manufacturing highly specific, consistent antibodies for the past three decades. My team of development scientists is continuously optimizing and tailoring immunogen and immunization protocols to generate antibodies with outstanding performance in a desired application. In addition, we have progressively utilized modern recombinant techniques to obtain the ideal fragments or engineered antibodies for our clients.
All our custom projects are handled by the same development scientists who produced the trusted antibodies offered on our retail catalog. Together with a dedicated project manager, my team will produce the ideal reagents to meet your research and development needs.
Julia Hatler, Ph.D.
Director of the Antibody Business Unit, R&D Systems
Apply our decades of conjugation experience to your project. Our scientists will apply the appropriate protocols to your project to ensure the final conjugate meets your needs. From detection antibodies for immunoassays, to flow cytometry conjugates, we can provide small to large scale antibody conjugation with a fast turnaround and fully tested end material. Available conjugates include:
- Alkaline Phosphatase
- Alexa Fluor® 350, 405, 488
- Alexa Fluor® 647, 700, 750
- PerCP, FITC, PE, APC
Antibody Characterization Services
Reproducibility is critical in your research. Identify key criterial for your antibody and receive fully characterized antibodies that meet those specifications.
- Specificity confirmation by direct ELISA
- Concentration determination
- Purity by SDS-PAGE
- Aggregation by SEC-HPLC
- Cross-reactivity testing
- Endotoxin levels by LAL
- Custom fill and finish
Manufacturing and GMP Conversion
Using established procedures, we manufacture antibodies for drug discovery, diagnostic, and cell ex vivo use under research or GMP regulatory requirements. All GMP antibody manufacturing is completed recombinantly and starts with conversion of your hybridoma-derived antibody to an immortal recombinant antibody.
Ensure a consistent supply of your critical antibody through our established scale up and manufacturing processes.
Anti-Idiotype Antibody Development
Anti-idiotypic antibodies play a critical role in antibody drug development. Using our established processes, we can quickly design an immunization strategy to generate anti-idiotypic antibodies specific to your antibody drug.
By understanding your goals, we will target antibodies for binding or blocking for your specific pharmacokinetic and immunogenicity studies.
Host Cell Protein Antibody Development
We can develop Host Cell Protein antibodies that are tailored to your cell line and specific to your process. Combine this with full assay development on our Luminex, Quantikine ELISA, or Ella platforms to provide an integral tool to your development process.
Simplify your sample analysis by utilizing our existing expertise in assay optimization on our ProteinSimple platforms. We will design an assay using our extensive antibody selection for rapid single cell or sample protein analysis. Explore our ProteinSimple platforms:
- Simple Western – analyze proteins by size from 2-440 kDa
- Simple Plex – automated immunoassays
- Single-Cell Westerns – measure cell subpopulatons
Conversion of our traditional monoclonal to recombinant antibody offered immortal supply of a very high quality product. We also liked the feature of the recombinant technology to be able to exchange the constant chain between different species and the ability to express the antibody as Fab fragments.
Principal Scientist, Biotech Company
Baseline samples taken one week apart from 15 cynomolgus monkeys were obtained from a Genentech study conducted at Charles River Laboratories (Reno, NV, USA). Positive controls from three sources were used: human IgG-cyno IgG fusion molecule produced for Genentech at R&D Systems (Minneapolis, MN).
Journal of Immunology Research
Volume 2016, Article ID 2618575