Blog

Stem Cells in the News - December 2018

星期五, 十一月 30, 2018 - 11:01
Stem Cells in the News

We have captured this month’s most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

Stem Cells in the News - November 2018

星期三, 十月 31, 2018 - 10:02
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

Drug Target Review

Researchers at the University of Colorado Cancer Center have found the upregulation of CDK1 and its direct interaction with Sox2 play a crucial role in the development...

Stem Cells in the News - October 2018

星期一, 十月 8, 2018 - 13:37
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

Utilizing Extracellular Matrix to Enhance Multicellular Tumor Spheroid Models for Proliferation and Invasion

星期五, 九月 21, 2018 - 08:47

This technical video provides an overview of the methodologies, tools, and reagents used to generate multicellular tumor spheroids. Specifically, this video discusses the benefits of Cultrex® extracellular matrices for spheroid formation and analysis. Technical tips are provided for using colorimetric and fluorometric assays to evaluate cell proliferation and invasion of spheroids.

This protocol video was originally recorded by Dr. Gabriel Benton at Trevigen, Inc. The Trevigen portfolio, including tools for creating 3-D and spheroid cultures, are now a part of R&D Systems, a Bio-Techne brand.

In this technical video you will learn:

  • Evolution of extracellular matrices used for 3-D cell culture
  • Benefits and challenges of spheroid models
  • Methods for spheroid formation
  • Tips...

Stem Cells in the News – September 2018

星期五, 八月 31, 2018 - 09:30
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

EurekaAlert!

A new study published in Tissue Engineering this month suggests that platelet-rich-plasma (PRP) does not promote or enhance...

R&D Systems Website Enhancements

星期二, 八月 14, 2018 - 13:20
New website enhancements

We are excited to launch new changes to the R&D Systems site! The site has new functionality and design to enhance the overall customer experience.  Some changes that you will see on the site:

  • Responsive Layout: The website will size appropriately to the device that you are using, including desktop computers, mobile phones, and tablets.
     
  • Datasheets/Product Data Pages: A new layout for the entire page for all the tabs and sections. You can filter product reviews, find related products and scroll through images in the new lightbox.
     
  • Luminex Assay Customization Tool...

Stem Cells in the News - August 2018

星期五, 八月 3, 2018 - 10:11
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

ScienceDaily

Researchers from Osaka University have recently published findings revealing the importance of SATB1 protein in the self-...

Welcome to our Summer Protein Update

星期三, 八月 1, 2018 - 08:19
New Proteins , Webinars and Resources
 

New Products

Recombinant Human DLL3
Recombinant Human DLL3 Now Available
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. It has received much recent attention due to its potential as a target for small cell lung cancer.
 
...

Webinar Short: CellXVivo™ Kits for the Differentiation or Expansion of Immune Cells

星期三, 七月 11, 2018 - 13:17

Watch this short video highlighting our CellXVivo™ kits developed for the consistent differentiation and expansion of T cells subtypes, dendritic cells, B cells, cytotoxic cells, and more. Kits include buffers, cytokines and optimized protocols for easy and reproducible cell culture.

Learn More About CellXVivo™ Immune Cell Differentiation and Expansion Kits

Recorded June 15, 2018

Bio-Techne Go Everywhere Travel Grant – June 2018 Recipient Selected!

星期日, 七月 8, 2018 - 12:23
Bio-Techne Travel Grants

Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.

The recipient of the June 2018 grant is Lucy McDermott, a PhD Student in the Nuffield Department of Clinical Neurosciences at the University of Oxford in Oxford, England.

...

Immunology News: Targeting Myeloid-Derived Suppressor Cells (MDSCs) for Cancer Immunotherapy

星期二, 七月 3, 2018 - 08:24
MDSC

Myeloid-derived suppressor cells (MDSCs) are a diverse population of immature myeloid cells with immunosuppressive properties that accumulate under pathological conditions including specific types of cancer and infections. Two primary subsets of human and mouse MDSCs known as granulocytic and monocytic MDSCs have been identified. These cells are of great interest as high levels of circulating MDSCs in cancer patients have been shown to correlate with clinical stage, metastatic burden, and resistance to both chemotherapy and immunotherapy. As a result, MDSCs are now recognized as a major obstacle in the treatment of cancer. Multiple strategies targeting these cells are being investigated to determine if the...

Stem Cells in the News - July 2018

星期一, 七月 2, 2018 - 14:03
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

The Scientist

A whistleblower in the misconduct case at the Karolinska...

Validating Antibodies to Support the AstraZeneca Drug Discovery Pipeline

星期一, 七月 2, 2018 - 08:15
Validating Antibodies to Support the AstraZeneca Drug Discovery Pipeline

Antibodies are critical tools in the majority of research and clinical studies. However, unreliable antibodies with poor specificity or reproducibility remain a significant drain on resources across biomedical research and industry. Widespread acceptance of the need for end-user antibody validation has led to high profile initiatives and guidance (e.g. Uhlen et al, Nat. Methods 2016). Aligning to these principles, the AstraZeneca Affinity Reagent Group provides company-wide advice and scientific support in the validation of both commercial and our bespoke antibodies generated in-house. Our work feeds into activities across the drug discovery pipeline, including target identification / validation, hit-...

ISSCR 2018 - Highlighting Stem Cell Therapy and 3-D Modeling

星期四, 六月 28, 2018 - 14:43
Another exciting International Society for Stem Cell Research (ISSCR) Annual Meeting has concluded

Another exciting International Society for Stem Cell Research (ISSCR) Annual Meeting has concluded. This year’s meeting, held in Melbourne, Australia (June 19-22nd, 2018), enabled the local stem cell research community to shine with many plenary talks, scientific presentations, and posters provided by researchers from Melbourne Universities and Hospitals. It was impressive! Many stem cell scientists were unable to attend the meeting due to the exotic and remote location. This summary will provide a snapshot of scientific themes and interesting science featured at the meeting.

Stem Cell Therapy

ISSCR 2018 was bookended by two invigorating symposia highlighting...

Advancing the Culture and Clonogenic Analysis of Gastrointestinal Stem Cells

星期二, 六月 19, 2018 - 09:19

In this webinar, Drs. Wa Xian and Frank McKeon, detail their work advancing model systems of the gastrointestinal tract. Specifically, their research focuses on utilizing a powerful system for the isolation, clonogenic culture, and differentiation of adult gastrointestinal stem cells, as described in Wang, X. et al (2015) Nature 522:173. They discuss why their system is vastly more simple and robust than the induced pluripotent stem cell (iPSC) and organoid platforms that presently dominate gastrointestinal research, how it is the only system that enables the dissection of stem cell heterogeneity underlying human disease, and why it is ideal for genome editing, autologous transplantation, large scale pathway analysis, and disease modeling. Their research is...

The Heat Is On: Detecting Chemokine Receptors on Live Cells

星期五, 六月 15, 2018 - 13:14
CCR7

Chemokine receptors and other multipass proteins require special consideration when staining live cells for flow cytometry analysis. These receptors have seven transmembrane domains, all of which are fluid and moving around in the cell membrane. As a result, the three extracellular loops, to which antibodies must bind, are also moving and this motion can change the orientation of antibody binding sites. While this domain flexibility is necessary for ligand binding to the receptor, it can create problems for flow cytometry staining of live cells. In addition to movement within the lipid membrane, chemokine receptors can undergo internalization and endocytic recycling,...

Bio-Techne Go Everywhere Travel Grant – May 2018 Recipient Selected!

星期一, 六月 11, 2018 - 10:24
Bio-Techne travel grants

May 2018 Go Everywhere with Bio-Techne Travel Grant Awarded to PhD Student from the University of Padova!

Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.

The recipient of the May 2018 grant is Diana Piol, a PhD Student in the Biomedical Sciences department at the University of Padova in Padova, Italy!

...

What Are the AT(N) Biomarkers for Alzheimer’s Disease?

星期五, 六月 8, 2018 - 10:42
Atlanta Biological Fetal Bovine Serum and Media

Researchers have long been attempting to identify and validate specific biomarkers for Alzheimer’s disease (AD). AD is a neurodegenerative disorder that is characterized by brain atrophy resulting from neuronal loss. It is typically diagnosed following a series of clinical assessments that include neurological and mental examinations and brain imaging. However, since many other disorders also display AD-like symptoms, the only way to definitively diagnosis AD is by tying clinical assessment of the disease to the postmortem identification of its pathological hallmarks (i.e. senile plaques...

Stem Cells in the News - June 2018

星期四, 五月 31, 2018 - 08:14
Stem Cells in the News

We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.

Evaluating New 3-D Systems for Disease Modeling, Drug Validation, and Toxicology

星期三, 五月 30, 2018 - 16:31

Cell and tissue-based models are a necessary step in the workflow for toxicology testing, drug discovery*, and disease modeling. In recent years, the research and pharmaceutical industries have adopted more complex ex vivo and in vitro 3-D tissue models because of their better predictive power. The first part of this webinar discusses the history of cell- and tissue-based models systems for toxicology, drug validation, and disease modeling. Particular emphasis will be placed on culture methods and optimization of stem cell-based models and 3-D cell culture systems, including organoids. The second half of the webinar introduces MimEX Tissue Model Systems, a transformative culturing platform that builds upon the...

Fourth Annual University of Minnesota Neuro-Oncology Symposium

星期二, 五月 15, 2018 - 10:39
Fourth Annual Minnesota Neuro-Oncology Symposium

Bio-Techne was pleased to be a sponsor of the 4th Annual University of Minnesota Neuro-Oncology Symposium. The preclinical Provider/Researcher program included 4 sessions: Physics and Modeling, Blood Brain Barrier, Genetics, and Immunotherapy/Emerging Therapies.  The clinical Patient/Caregiver program included 2 sessions: Treatment & Therapies and Living with a Brain Tumor.

The Physics and Modeling Session focused mostly on cell culture model systems....

Quarterly Antibody Product and Data Update: Edition #1

星期五, 五月 11, 2018 - 14:29
Antibody Product Update

New Products and Antibody Validation

Recombinant Antibodies
New Recombinant Antibodies Added Every Week: Over 700 Antibodies and Growing
Biology introduces more than enough variability for researchers to worry about without adding inconsistent reagents to the equation. Start minimizing one major source of experimental variability in your research by using recombinant antibodies. We...

Bio-Techne Go Everywhere Travel Grant – April 2018 Recipient Selected!

星期三, 五月 9, 2018 - 07:44
Bio-Techne Travel Grants

Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.

The recipient of the April 2018 grant is Linda Ban, a PhD Candidate in the Endocrinology department at the University of Sydney!

Linda has chosen to apply the grant to the ANZOS & Breakthrough Discoveries 2018 Joint Conference in Melbourne, Australia from October 16-18, 2018.

...

Bio-Techne: A Leader in Autophagy Research

星期二, 五月 8, 2018 - 08:30
Press Release Bio-Techne

Bio-Techne: A Leader in Autophagy Research

Bio-Techne and our family of brands provide a unique portfolio of products and services that support basic research, and we are positioning ourselves as a leader in the autophagy field through the support of several autophagy-focused conferences in 2018 and by sharing our autophagy research with the scientific community at these conferences.

Our commitment to high-quality reagents and services was recently honored by CiteAb, which identified our LC3B antibody (catalog #NB100-2220...

Turning Flow Cytometry Upside Down and Inside Out: Cellular Function Revealed

星期二, 五月 8, 2018 - 07:58

Flow cytometry is a powerful technique that allows researchers to examine multiple proteins on cell populations using fluorescently labeled antibodies. Multi-parameter, fluidic-based flow cytometry has been applied to multiple fields of study ranging from basic to clinical immunology, cancer biology, neuroscience, stem cell research, and drug discovery. In order to maximize the quality of results obtained using this technology, researchers should be familiar with the basics of flow cytometry when setting up an experiment. In this series of seminars, we will discuss the necessary tools to design, run, and analyze a multi-parameter flow cytometric experiment.

Webinar 2 - Turning Flow Cytometry Upside Down and Inside Out: Cellular Function Revealed

In this webinar, you will learn how to apply basic concepts of flow cytometry...

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