2,4-Diamino-6-hydroxypyrimidine

Name: 2,4-Diamino-6-hydroxypyrimidine
Brand: Tocris Bioscience
SKU: 0476
Price: 49 USD

Catalog #: 0476 Datasheet / COA / SDS

Discontinued Product

0476 has been discontinued.

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2,4-Diamino-6-hydroxypyrimidine | CAS No. 56-06-4 | Additional NOS Inhibitors

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Description: Inhibits tetrahydrobiopterin synthesis and thus NOS activity

Purity: ≥99%

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Biological Activity

2,4-Diamino-6-hydroxypyrimidine is a GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).

Technical Data

M.Wt:

126.12

Formula:

C₄H₆N₄O

Solubility:

Soluble in DMSO

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

56-06-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence.
Charles et al.
Eur.J.Pharmacol., 2019;848
Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system?
Moore and Handy
TiPS, 1997;18:204
GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine.
Xie et al.
J.Biol.Chem., 1998;273:21091
Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP.
Werner-Felmayer et al.
J.Biol.Chem., 1993;268:1842

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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