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2,4-Dihydroxyphenylacetyl-L-asparagine

Catalog #: 0262 Datasheet / COA / SDS

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2,4-Dihydroxyphenylacetyl-L-asparagine | CAS No. 111872-98-1 | Glutamate Receptor Compounds
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Description: Component of Joro spider toxin
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Biological Activity

Constituent of various spider toxins. Reported to be specific blocker of glutamate receptors.

Technical Data

M.Wt:
282.25
Formula:
C12H14N2O6
Solubility:
Soluble to 50 mM in water
Storage:
Desiccate at -20°C
CAS No:
111872-98-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibitory effect of 2,4-dihydroxyphenylacetylasparagine, a common moiety of spider toxin, on glutamate binding to rat brain synaptic membranes.
    Pan-Hou et al.
    Neurosci.Lett., 1987;81:199
  2. A spider toxin (JSTX) inhibits L-glutamate uptake by rat brain synaptosomes.
    Pan-Hou et al.
    Brain Res., 1989;476:354
  3. Mechanisms of neurotoxicity of low molecular weight spider toxins.
    Usherwood et al.
    Basic Science in Toxicology. Ed. G.N. Volans, 1990;:569

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