2B-(SP)
Description: Selective GSK-3 phosphopeptide substrate
Biological Activity
2B-(SP) is a selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3); derived from the phosphorylation site of the translation factor eIF2B.Technical Data
M.Wt:
1835.88
Formula:
C71H123N26O29P
Sequence:
RRAAEELDSRAGSPQL
(Modifications: Ser-13 = pSer)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
186901-17-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Site-specific phosphorylation protects glycogen synthase kinase-3β from calpain-mediated truncation of its N and C termini.
Ma S, Liu S, Huang Q, Xie B, Lai B, Wang C, Song B, Li M
J. Biol. Chem., 2012;287(27):22521-32. -
Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3β and Shaggy.
Williams et al.
FEBS Lett., 1999;448:86 -
Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.
Welsh et al.
Anal.Biochem., 1997;244:16
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