Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Biological Activity7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.
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Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.
Jiang et al.
7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats.
Andero et al.
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.
Jang et al.
Citations for 7,8-Dihydroxyflavone
The citations listed below are publications that use Tocris products. Selected citations for 7,8-Dihydroxyflavone include:
10 Citations: Showing 1 - 10
Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex.
Authors: Kee K Et al.
Dis Model Mech 2022;15
Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction.
Authors: Greising Et al.
Physiol Rep 2017;5
Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas.
Authors: Shamblott Et al.
Cell Communication and Signaling 2016;14:23
Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins.
Authors: Chitranshi Et al.
Purinergic Signal 2015;16:21087
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
Authors: Chen Et al.
Eur J Neurosci 2014;39:1439
Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
Authors: Al-Qudah Et al.
Am J Physiol Gastrointest Liver Physiol 2014;306:G328
TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea.
Authors: Meltser Et al.
Curr Biol 2014;24:658
Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs.
Authors: Choi Et al.
Muscle Nerve 2013;59:450
Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle.
Authors: Abcejo Et al.
Int J Mol Sci 2012;7:e44343
The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.
Authors: Mantilla and Ermilov
PLoS One 2012;45:274
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