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7,8-Dihydroxyflavone | CAS No. 38183-03-8 | Trk Receptor Agonists
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Description: TrkB agonist
Alternative Names: 7,8-DHF

Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (10)
Supplemental Products

Biological Activity

7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.
    Jiang et al.
    Hum.Mol.Genet., 2013;22:2462
  2. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats.
    Andero et al.
    Hippocampus, 2012;22:399
  3. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.
    Jang et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:268

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Citations for 7,8-Dihydroxyflavone

The citations listed below are publications that use Tocris products. Selected citations for 7,8-Dihydroxyflavone include:

10 Citations: Showing 1 - 10

  1. Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex.
    Authors: Kee K Et al.
    Dis Model Mech  2022;15
  2. Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction.
    Authors: Greising Et al.
    Physiol Rep  2017;5
  3. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas.
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  4. Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins.
    Authors: Chitranshi Et al.
    Purinergic Signal  2015;16:21087
  5. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
    Authors: Chen Et al.
    Eur J Neurosci  2014;39:1439
  6. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
    Authors: Al-Qudah Et al.
    Am J Physiol Gastrointest Liver Physiol  2014;306:G328
  7. TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea.
    Authors: Meltser Et al.
    Curr Biol  2014;24:658
  8. Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs.
    Authors: Choi Et al.
    Muscle Nerve  2013;59:450
  9. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle.
    Authors: Abcejo Et al.
    Int J Mol Sci  2012;7:e44343
  10. The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.
    Authors: Mantilla and Ermilov
    PLoS One  2012;45:274


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