Azoramide

Name: Azoramide
Brand: Tocris Bioscience
SKU: 5796

Catalog #: 5796 Datasheet / COA / SDS

Discontinued Product

5796 has been discontinued.

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Azoramide | CAS No. 932986-18-0 | Other ER Stress/UPR Modulators

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Description: Unfolded protein response (UPR) modulator

Chemical Name: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide

Purity: ≥98%

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Biological Activity

Modulator of unfolded protein response (UPR). Protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER calcium retention. Improves liver ER function, glucose homeostasis and glucose-stimulated insulin secretion in mouse obesity models. Orally bioavailable.

Technical Data

M.Wt:

308.83

Formula:

C₁₅H₁₇ClN₂OS

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

932986-18-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.
Fu et al.
Sci.Transl.Med., 2015;7:292ra98

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