BD 1008 dihydrobromide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition.
   Whittemore et al.
   J.Pharmacol.Exp.Ther., 1997;282:326
3. Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor.
   De Costa et al.
   J.Med.Chem., 1992;35:38
4. Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [³H]-noradrenaline release in rat hippocampal slices.
   Monnet et al.
   Br.J.Pharmacol., 1996;119:65

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