BRL 15572 hydrochloride

Name: BRL 15572 hydrochloride
Brand: Tocris Bioscience
SKU: 1207

Catalog #: 1207
3 Citations Datasheet / COA / SDS

Discontinued Product

1207 has been discontinued.

View all 5-HT1D Receptor Antagonists products.

BRL 15572 hydrochloride | CAS No. 1173022-77-9 | 5-HT1D Receptor Antagonists

1 Image

Description: Selective h5-HT1D antagonist

Chemical Name: 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride

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Product Details

Citations (3)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

BRL 15572 hydrochloride is a selective h5-HT_1D antagonist, displaying 60-fold selectivity over h5-HT_1B, and exhibiting little or no affinity for a range of other receptor types.

Technical Data

M.Wt:

443.42

Formula:

C₂₅H₂₇ClN₂O.HCl

Solubility:

Soluble to 10 mM in DMSO and to 50 mM in ethanol

Storage:

Desiccate at +4°C

CAS No:

1173022-77-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of GlaxoSmithKline

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Stimulation of 5-HT_1B receptors causes hypothermia in the rat.
Hagan et al.
Eur.J.Pharmacol., 1997;331:169
SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT_1B and h5-HT_1D receptors.
Price et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:312
5-HT₁-like receptors: a time to bid goodbye.
Saxena et al.
TiPS, 1998;19:311
Effects of selective h5-HT_1B (SB-216641) and h5-HT_1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors.
Schlicker et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:321

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for BRL 15572 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BRL 15572 hydrochloride include:

3 Citations: Showing 1 - 3

Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
Authors: Baillie Et al.
World J Gastroenterol 2012;63:362
Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat.
Authors: McDaid and Docherty
Br J Pharmacol 2001;133:429

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