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Conessine

Catalog #: 2409 Datasheet / COA / SDS

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2409 has been discontinued.
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Conessine | CAS No. 546-06-5 | Histamine H3 Receptor Antagonists
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Description: Potent and selective H3 receptor antagonist

Chemical Name: N,N-Dimethyl-con-5-enin-3-amine

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Biological Activity

Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).

Technical Data

M.Wt:
356.59
Formula:
C24H40N2
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
546-06-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
    Zirihi et al.
    Bioorg.Med.Chem.Lett., 2005;15:2637
  2. The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
    Zhao et al.
    J.Med.Chem., 2008;51:5423
  3. Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist.
    Witte et al.
    Soc.Neurosci.Abstr., 2005;491:19

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