Dihydrosphingosine

Name: Dihydrosphingosine
Brand: Tocris Bioscience
SKU: 0749

Catalog #: 0749 Datasheet / COA / SDS

Discontinued Product

0749 has been discontinued.

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Dihydrosphingosine | CAS No. 3102-56-5 | Protein Kinase C Inhibitors

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Description: Protein kinase C inhibitor

Alternative Names: Sphinganine

Chemical Name: DL-erythro-1,3-Dihydroxy-2-aminooctadecane

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Protein kinase C inhibitor.

Technical Data

M.Wt:

301.51

Formula:

C₁₈H₃₉NO₂

Solubility:

Soluble to 100 mM in DMSO

Storage:

Desiccate at -20°C

CAS No:

3102-56-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.
Mercado, Nicolas, Kizawa, Yasuo, Ueda, Keitaro, Xiong, Yeping, Kimura, Genki, Moses, Audric, Curtis, Jonathan, Ito, Kazuhiro, Barnes, Peter J
PLoS ONE, 2014;9(2):e88168.
Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells.
Yung et al.
Biochem.Biophys.Res.Commun., 1993;196:1390
Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60).
Yung et al.
Biochem.Biophys.Res.Commun., 1994;199:888

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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