Efaroxan hydrochloride
Discontinued Product
Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride
Purity: ≥99%
Biological Activity
Efaroxan hydrochloride is a potent, highly selective α2 adrenoceptor antagonist and imidazoline I1 receptor ligand (pKi values are 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A, α2B, α2C, I1, and I2 receptors respectively). Promotes insulin secretion, at a site distinct from I1 or I2 (the putative I3 receptor) in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
'Seeing through a glass darkly': casting light on imidazoline 'I' sites.
Eglen et al.
TiPS, 1998;19:381 -
α-Adrenoceptor reagents 2. Effects of modification of the 1,4-benzodioxan ring system on α-adrenoceptor activity.
Chapleo et al.
J.Med.Chem., 1984;27:570 -
Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse.
Mayer and Taberner
Eur.J.Pharmacol., 2002;454:95 -
Imidazolines stimulate release of Ins from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
Olmos et al.
Eur.J.Pharmacol., 1994;262:41
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