GR 135531

Name: GR 135531
Brand: Tocris Bioscience
SKU: 0896

Catalog #: 0896
5 Citations Datasheet / COA / SDS

Discontinued Product

0896 has been discontinued.

View all Melatonin (MT) Receptor Ligands products.

GR 135531 | CAS No. 190277-13-5 | Melatonin (MT) Receptor Ligands

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Description: High affinity melatonin MT3 ligand

Alternative Names: 5-MCA-NAT

Chemical Name: 5-Methoxycarbonylamino-N-acetyltryptamine

Purity: ≥97%

View All Products for Melatonin (MT) Receptor Ligands

Product Details

Citations (5)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Binds with high affinity to MT₃ melatonin sites in hamster brain, and low affinity (and no efficacy) at MT₁ and MT₂ melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.

Technical Data

M.Wt:

275.31

Formula:

C₁₄H₁₇N₃O₃

Solubility:

Soluble to 100 mM in ethanol

Purity:

≥97%

Storage:

Store at RT

CAS No:

190277-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Melatonin receptors: are there multiple subtypes?
Dubocovich
TiPS, 1995;16:50
Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT₄ and melatonin receptors.
Lucchelli et al.
Br.J.Pharmacol., 1997;121:1775

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for GR 135531

The citations listed below are publications that use Tocris products. Selected citations for GR 135531 include:

5 Citations: Showing 1 - 5

Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability.
Authors: Loma Et al.
J Neurosci 2015;172:1045
Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma.
Authors: Crooke Et al.
J Pharmacol Exp Ther 2013;346:138
MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
Authors: Tunstall Et al.
Br J Pharmacol 2011;336:127
Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
Authors: Kojima Et al.
Br J Pharmacol 2011;162:1179
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Authors: Sjöblom Et al.
J Pharmacol Exp Ther 2001;108:625

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