ICI 162,846
Discontinued Product
Chemical Name: N-[1-(4-Carboxamidobutyl)-1H-pyrazol-3-yl)]-N'-(2,2,2-trifluoroethyl)guanidine
Biological Activity
ICI 162,846 is a potent histamine H2 receptor antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model.
Gompertz et al.
Agents Actions, 1991;33:161 -
Inhibition of human gastric secretion by ICI 162,846 - a new histamine H2 receptor antagonist.
Wilson et al.
Br.J.Clin.Pharmacol., 1986;21:685 -
Morphological stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846.
Streett et al.
Toxicol.Pathol., 1988;16:299
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