Home / IL-12 p70 / IL-12 p70/IL-12A [Unconjugated]

IL-12 p70/IL-12A [Unconjugated]

Catalog #: LUM419
13 Citations Datasheet / COA / SDS
Newer Version Available: LXSAMSM
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Discontinued Product

LUM419 has been discontinued and is replaced by LXSAMSM.

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Citations (13)
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IL-12 p70/IL-12A [Unconjugated] Summary

Product Datasheets

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COA
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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: IL-12 p70

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

Long Name
Interleukin 12 p70
Entrez Gene IDs
3592 (Human); 16159 (Mouse); 84405 (Rat)
Alternate Names
IL12 p70; IL-12 p70

Citations for IL-12 p70/IL-12A [Unconjugated]

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

13 Citations: Showing 1 - 10
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  1. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease.
    Authors: Chantrathammachart P, Mackman N, Sparkenbaugh E
    Blood, 2012-06-01;120(3):636-46.
    Species: Mouse
    Sample Types: Plasma
  2. Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state.
    Authors: de Claro RA, Zhu X, Tang J, Morgan-Stevenson V, Schwartz BR, Iwata A, Liles WC, Raines EW, Harlan JM
    Am. J. Pathol., 2011-05-06;178(6):2931-7.
    Species: Mouse
    Sample Types: Plasma
  3. The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region.
    Authors: Herrero R, Kajikawa O, Matute-Bello G
    J. Clin. Invest., 2011-03-01;121(3):1174-90.
    Species: Mouse
    Sample Types: Tissue Homogenates
  4. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.
    Authors: Gill SE, Huizar I, Bench EM
    Am. J. Pathol., 2009-12-11;176(1):64-73.
    Species: Mouse
    Sample Types: BALF
  5. Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice.
    Authors: Smith LS, Gharib SA, Frevert CW, Martin TR
    Am. J. Respir. Cell Mol. Biol., 2009-11-09;43(4):475-86.
    Species: Mouse
    Sample Types: Tissue Homogenates
  6. 3',5'-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection.
    Authors: Yan H, KuoLee R, Tram K, Qiu H, Zhang J, Patel GB, Chen W
    Biochem. Biophys. Res. Commun., 2009-07-16;387(3):581-4.
    Species: Mouse
    Sample Types: BALF
  7. Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming.
    Authors: Highfill SL, Kelly RM, O'Shaughnessy MJ, Zhou Q, Xia L, Panoskaltsis-Mortari A, Taylor PA, Tolar J, Blazar BR
    Blood, 2009-05-20;114(3):693-701.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  8. Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis.
    Authors: Wang H, Zhang W, Zhu C, Bucher C, Blazar BR, Zhang C, Chen JF, Linden J, Wu C, Huo Y
    Arterioscler. Thromb. Vasc. Biol., 2009-04-30;29(7):1046-52.
    Species: Mouse
    Sample Types: Plasma
  9. Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia.
    Authors: Ventura CL, Higdon R, Hohmann L, Martin D, Kolker E, Liggitt HD, Skerrett SJ, Rubens CE
    Infect. Immun., 2008-10-13;76(12):5862-72.
    Species: Mouse
    Sample Types: BALF
  10. Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients.
    Authors: Swee M, Wilson CL, Wang Y, McGuire JK, Parks WC
    J. Leukoc. Biol., 2008-03-11;83(6):1404-12.
    Species: Mouse
    Sample Types: Tissue Homogenates
  11. A new murine model for bronchiolitis obliterans post-bone marrow transplant.
    Authors: Panoskaltsis-Mortari A, Tram KV, Price AP, Wendt CH, Blazar BR
    Am. J. Respir. Crit. Care Med., 2007-06-15;176(7):713-23.
    Species: Mouse
    Sample Types: Serum
  12. Essential role of MMP-12 in Fas-induced lung fibrosis.
    Authors: Matute-Bello G, Wurfel MM, Lee JS, Park DR, Frevert CW, Madtes DK, Shapiro SD, Martin TR
    Am. J. Respir. Cell Mol. Biol., 2007-04-19;37(2):210-21.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  13. Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation.
    Authors: Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC
    J. Immunol., 2005-09-01;175(5):3369-76.
    Species: Mouse
    Sample Types: BALF

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