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L-165,041

Catalog #: 1856
2 Citations Datasheet / COA / SDS

Discontinued Product

1856 has been discontinued.
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L-165,041 | CAS No. 79558-09-1 | PPAR delta Receptor Agonists
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Description: Potent PPARδ agonist

Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.

Technical Data

M.Wt:
402.44
Formula:
C22H26O7
Solubility:
Soluble to 50 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
79558-09-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of the peroxisome proliferator-activated receptor (PPAR)-delta agonist GW501516 on bone and muscle in ovariectomized rats.
    Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, Eriksen E, Syversen U
    Endocrinology, 2014;155(6):2178-89.
  2. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells.
    Jia B, Madsen L, Petersen RK, Techer N, Kopperud R, Ma T, Doskeland SO, Ailhaud G, Wang J, Amri EZ, Kristiansen K
    PLoS ONE, 2012;7(3):e34114.
  3. Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects.
    Berger et al.
    J.Biol.Chem., 1999;274:6718
  4. Activation of PPARδ alters lipid metabolism in db/db mice.
    Leibowitz et al.
    FEBS Lett., 2000;473:333
  5. Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo.
    Iwashita et al.
    J.Pharmacol.Exp.Ther., 2007;320:1087

Product Datasheets

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Citations for L-165,041

The citations listed below are publications that use Tocris products. Selected citations for L-165,041 include:

2 Citations: Showing 1 - 2

  1. PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth.
    Authors: Martín-Martín Et al.
    Cancer Res  2018;78:399
  2. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
    Authors: Mottillo Et al.
    J Mol Graph Model  2012;287:25038

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