Mouse Wnt-3a DuoSet ELISA

Name: Mouse Wnt-3a DuoSet ELISA
Brand: R&D Systems
SKU: DY1324

Catalog #: DY1324
3 Citations Datasheet / COA / SDS

Newer Version Available: DY1324B-05

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Discontinued Product

DY1324 has been discontinued and is replaced by DY1324B-05.

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Citations (3)

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Summary Product Datasheets Preparation and Storage Background

Mouse Wnt-3a DuoSet ELISA Summary

Assay Range

250.0 - 16,000 pg/mL

Specificity

Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

Product Datasheets

Product Datasheet

COA

SDS

Preparation and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Wnt-3a

Wnt-3a is a secreted protein that is necessary for proper embryonic development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation. It also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells. The post-translational glycosylation and acylation of Wnts are essential for their efficient secretion and biological activity, respectively. Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta-catenin levels. As intracellular beta-catenin levels rise, beta-catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes.

Long Name:

Wingless-type MMTV Integration Site Family, Member 3a

Entrez Gene IDs:

89780 (Human); 22416 (Mouse)

Alternate Names:

MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a

Citations for Mouse Wnt-3a DuoSet ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
Authors: N Azazmeh, B Assouline, E Winter, S Ruppo, Y Nevo, A Maly, K Meir, AK Witkiewicz, J Cohen, SV Rizou, E Pikarsky, C Luxenburg, VG Gorgoulis, I Ben-Porath
Nat Commun, 2020-06-01;11(1):2711.
Species: Mouse
Sample Types: Cell Culture Supernates
Attenuation of Wnt/beta-catenin signaling in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis
Authors: CB Chen, WC Chang, MY Wu, TY Kao, YW Wang, CW Wang, CJ Chen, WH Chung, SC Su
Int. J. Biol. Sci., 2020-01-01;16(2):353-364.
Species: Human
Sample Types: Serum
Fenretinide, Tocilizumab & Reparixin Provide Multifaceted Disruption of Oral Squamous Cell Carcinoma Stem Cell Properties: Implications for Tertiary chemoprevention
Authors: SR Mallery, D Wang, B Santiago, P Pei, C Bissonnett, JA Jayawarden, SP Schwendema, R Spinney, J Lang
Mol. Cancer Ther., 2019-09-12;0(0):.
Species: Human
Sample Types: Cell Culture Supernates