NU 1025
Discontinued Product
Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone
Purity: ≥99%
Biological Activity
NU 1025 is a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
Bowman et al.
Br.J.Cancer., 1998;78:1269 -
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Griffin et al.
J.Med.Chem., 1998;41:5247 -
Potentiation of temozol. and topo. growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.
Delaney et al.
Clin.Cancer.Res., 2000;6:2860
Product Datasheets
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Citation for NU 1025
The citations listed below are publications that use Tocris products. Selected citations for NU 1025 include:
1 Citation: Showing 1 - 1
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Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
Authors: Sultana Et al.
Int J Cancer 2012;131:2433
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