Peptide F9
Description: Inhibits laminin-mediated cell adhesion and migration
Biological Activity
Peptide derived from the heparin-binding domain in the B1 chain of laminin. Binds to heparin, promotes cell adhesion, and inhibits the migration towards, and adhesion of metastatic fibrosarcoma cells to laminin.Technical Data
M.Wt:
2427.9
Formula:
C110H175N31O27S2
Sequence:
RYVVLPRPVCFEKGMNYTVR
Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
117609-40-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A novel synthetic peptide from the B1 chanin of laminin with heparin-binding and cell adhesion-promoting activities.
Charonis et al.
J.Cell Biol., 1988;107:1253 -
Laminin and heparan sulfate proteoglycan mediate epithelial cell polarization in organotypic cultures of embryonic lung cells: evidence implicating involvement of the inner globular region of laminin β 1 chain and the heparan sulfate groups of hepara
Schuger et al.
Dev.Biol., 1996;179:264 -
Definition of a sequence, RYVVLPR, within laminin peptide F-9 that mediates metastatic fibrosarcoma cell adhesion and spreading.
Skubitz et al.
Cancer Res., 1990;50:7612
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