Home / Additional RTK Inhibitors / PLX 647 dihydrochloride

PLX 647 dihydrochloride

Catalog #: 5102 Datasheet / COA / SDS

Discontinued Product

5102 has been discontinued.
View all Additional RTK Inhibitors products.
PLX 647 dihydrochloride | CAS No. 1779796-38-1 | Additional RTK Inhibitors
1 Image
Description: Potent dual Fms/KIT inhibitor

Chemical Name: 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride

Purity: ≥97%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PLX 647 dihydrochloride is a potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

Technical Data

M.Wt:
455.3
Formula:
C21H17F3N4.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1779796-38-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
    Zhang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:5689

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PLX 647 dihydrochloride

There are currently no reviews for this product. Be the first to review PLX 647 dihydrochloride and earn rewards!

Have you used PLX 647 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.