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RI-STAD 2

Catalog #: 6567 Datasheet / COA / SDS

Discontinued Product

6567 has been discontinued.
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RI-STAD 2
1 Image
Description: AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
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Biological Activity

RI-STAD 2 is an AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

Technical Data

M.Wt:
2401.75
Formula:
C109H181N25O35
Sequence:
LXQYAXQLADQIIKEATEK

(Modifications: Leu-1 = NH2-PEG3-CH2-CO-Leu, X = (S)-2-(4-pentenyl)alanine, X-2 and X-6 stapled together with a double bond)

Solubility:
Soluble to 1 mg/ml in 50% acetonitrile / water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PKA-type I selective constrained peptide disruptors of AKAP complexes.
    Wang et al.
    ACS Chem.Biol., 2015;10:1502

Product Datasheets

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