RWJ 21757
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Description: Toll-like receptor 7 (TLR7) agonist
Alternative Names: Loxoribine,7-Allyl-8-oxoguanosine
Chemical Name: 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
Purity: ≥97%
Biological Activity
Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.Technical Data
M.Wt:
339.3
Formula:
C13H17N5O6
Solubility:
Soluble to 20 mM in water and to 75 mM in DMSO
Purity:
≥97%
Storage:
Desiccate at +4°C
CAS No:
121288-39-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle.
Goodman et al.
Blood, 1994;84:3457 -
The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.
Heil et al.
Eur.J.Immunol., 2003;33:2987 -
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7.
Lee et al.
Proc.Natl.Acad.Sci.USA, 2003;100:6646
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