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SB 203186 hydrochloride

Catalog #: 0785 Datasheet / COA / SDS

Discontinued Product

0785 has been discontinued.
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SB 203186 hydrochloride | CAS No. 207572-69-8 | 5-HT4 Receptor Antagonists
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Description: 5-HT4 antagonist

Chemical Name: 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride

Purity: ≥99%

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Biological Activity

SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.

Technical Data

M.Wt:
308.81
Formula:
C16H20N2O2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
207572-69-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. 5-HT4 receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex.
    McLean and Coupar
    Naunyn Schmiedebergs Arch.Pharmacol., 1995;352:132
  3. Characterisation of 5-HT4 receptor mediating tachycardia in piglet isolated right atrium.
    Midhurst and Kaumann et al.
    Br.J.Pharmacol., 1993;110:1023
  4. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186.
    Parker et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1995;353:28

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