U-54494A hydrochloride
Chemical Name: cis-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide hydrochloride
Biological Activity
κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids in the hippocampus.
Proietti et al.
Neuropharmacology, 1991;30:637 -
U-54494A: a unique anticonvulsant related to kappa opioid agonists.
Voigtlander et al.
J.Pharmacol.Exp.Ther., 1987;243:542 -
Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, D.pam and phen.
Sethy and Sage
Neuropharmacology, 1992;31:111
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