8 results for "Inositol Lipid Inhibitors" in 产品
Inositol Lipid Inhibitors
In response to GPCR and receptor tyrosine kinase activation, PI 3-kinase phosphorylates some inositol lipids, such as PI(3,4,5)P3, and PLC mediates inositol lipid cleavage to generate further second messengers such as DAG and IP3. IP3 subsequently acts upon IP3 receptors located in the ER membrane and mediates Ca2+ release.
Regulation of inositol lipid signaling pathways is through phosphorylation (e.g. by inositol-tetrakisphosphate 1-kinase) and dephosphorylation (e.g. by inositol monophosphatase (IMPase)) of inositol lipids. This large group of proteins constitute a major intracellular signal transduction network. Because of this, inositol lipids are involved in a vast number of physiological processes.
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
| Chemical Name: | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride |
| Purity: | ≥99% |
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
| Alternate Names: | SL-2052 |
| Chemical Name: | (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione |
| Purity: | ≥98% |
Non-selective PI 3-kinase inhibitor
| Chemical Name: | 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one |
| Purity: | ≥98% |
Inhibitor of PI 3-kinase, mTOR and DNA-PK
| Chemical Name: | 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride |
| Purity: | ≥98% |
PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
| Chemical Name: | 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one |
| Purity: | ≥98% |
Inositol monophosphatase inhibitor
| Chemical Name: | [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid |
Class III PI 3-kinase inhibitor; also inhibits autophagy
| Alternate Names: | 3-MA |
| Chemical Name: | 3-Methyl-3H-purin-6-amine |
| Purity: | ≥98% |
Potent and selective PI 3-Kβ inhibitor
| Chemical Name: | (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid |
| Purity: | ≥98% |
