Ac-YVAD-AFC

Name: Ac-YVAD-AFC
Brand: Tocris Bioscience
SKU: 1572

Catalog #: 1572 Datasheet / COA / SDS

Discontinued Product

1572 has been discontinued.

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Description: Fluorogenic caspase-1 (ICE) substrate

Chemical Name: N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin)

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Product Details

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Biological Activity

Fluorogenic peptide substrate for caspase-1 (ICE).

Technical Data

M.Wt:

719.67

Formula:

C₃₃H₃₆F₃N₅O₁₀

Sequence:

YVAD

(Modifications: Tyr-1 = N-Ac-Tyr, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin))

Solubility:

Soluble to 14.39 mg/ml in DMSO

Storage:

Desiccate at -20°C

CAS No:

219137-85-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases.
Jones et al.
Hepatology, 1998;27:1632
Activation of caspase-3 and apoptosis in cerebellar granule cells.
Marks et al.
J.Neurosci.Res., 1998;52:334

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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