20 results for "Caspase Inhibitors" in Products

Caspase Inhibitors

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytoki...

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Reactivity: Multi-Species
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Caspase-3 Inhibitor

Purity: ≥95%
Caspase-3 Inhibitor
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Cell-permeable, irreversible caspase inhibitor

Chemical Name: Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Purity: ≥95%
Cell-permeable, irreversible caspase inhibitor
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Potent pan-caspase inhibitor

Chemical Name: N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
Purity: ≥98%
Potent pan-caspase inhibitor
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High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable

Alternate Names: Belnacasan
Chemical Name: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide
Purity: ≥98%
High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
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Potent and selective inhibitor of caspases 1, 5 and 4

Purity: ≥95%
Potent and selective inhibitor of caspases 1, 5 and 4
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Caspase-1 and NLRP3 inflammasome inhibitor

Chemical Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
Purity: ≥98%
Caspase-1 and NLRP3 inflammasome inhibitor
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NLRP3 inhibitor; active in vivo

Chemical Name: 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
Purity: ≥98%
NLRP3 inhibitor; active in vivo
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