Amyloid β-Peptide (1-43) (human)
Description: Amyloid β-protein fragment
Biological Activity
Amyloid β-Peptide (1-43) (human) is a human β-amyloid peptide; minor component of neuritic plaques found in brains of patients with Alzheimer's disease.Technical Data
M.Wt:
4615.19
Formula:
C207H318N56O62S
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIAT
Solubility:
Soluble to 1 mg/ml in acetic acid
Storage:
Desiccate at -20°C
CAS No:
134500-80-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Human and rodent sequence analogs of Alzheimer's amyloid βA4 share similar properties and can be solubilized in buffers of pH 7.4.
Hilbich et al.
Eur.J.Biochem., 1991;201:61 -
The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.
Jarrett et al.
Biochemistry, 1993;32:4693 -
Mass spectrometry of purified amyloid β protein in Alzheimer's disease.
Mori et al.
J.Biol.Chem., 1992;267:17082
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