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(±)-Cloprostenol sodium salt

Catalog #: 2295 Datasheet / COA / SDS

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(±)-Cloprostenol sodium salt | CAS No. 55028-72-3 | Prostanoid Receptor Agonists
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Description: Water-soluble PGF2α analog and potent FP receptor agonist

Chemical Name: (5Z)-rel-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid monosodium salt

Purity: ≥98%

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Biological Activity

(±)-Cloprostenol sodium salt is a water-soluble prostaglandin F2α (PGF2α) analog; acts as a potent FP receptor agonist (EC50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo.

Technical Data

M.Wt:
446.9
Formula:
C22H28ClNaO6
Solubility:
Soluble to 20 mM in water
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
55028-72-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent luteolytic agents related to prostaglandin F2α.
    Dukes et al.
    Nature, 1974;250:330
  2. Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization.
    Griffin et al.
    J.Pharmacol.Exp.Ther., 1998;286:411
  3. Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium.
    Serrero and Lepak
    Biochem.Biophys.Res.Comm., 2002;233:200

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