Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl
Biological ActivityHonokiol is an anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
Bai et al.
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Kim and Cho
Acta Pharmacol.Sinica, 2008;29:113
Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Dikalov et al.
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway.
Ahn et al.
Mol.Cancer Res., 2006;4:621
Citations for Honokiol
The citations listed below are publications that use Tocris products. Selected citations for Honokiol include:
2 Citations: Showing 1 - 2
Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice.
Authors: Melitta Et al.
Int J Mol Sci 2022;23
Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice.
Authors: Xu Et al.
Dis Model Mech 2017;10:1117
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