NFkB/IkB Inhibitors: Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes.

"NFkB/IkB Inhibitors" has 45 results in Products.
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MG 132

Proteasome and calpain inhibitor. Inhibits NF-κB activation
Newer Version Available: I-130-05M

Caffeic acid phenethyl ester

Specific inhibitor of NF-κB activation

Luteolin

Anti-inflammatory, antioxidant and free radical scavenger

Arctigenin

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

TPCA-1

Potent, selective inhibitor of IKKβ

HU 211

NMDA receptor antagonist; also NF-κB inhibitor

Triptolide

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

ACHP

Selective IKKα and IKKβ inhibitor

Amlexanox

Selective inhibitor of TBK

Bengamide B

Potent inhibitor of NF-κB activation

RAGE antagonist peptide

RAGE antagonist

Pyrrolidinedithiocarbamate ammonium

Inhibits NF-κB, prevents increase in NOS mRNA

Bay 11-7085

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Bay 11-7821

E2 ubiquitin (Ub) conjugating enzymes inhibitor

IKK 16

Selective inhibitor of IKK

Celastrol

Inhibits TNF-α-induced NF-κB activation

Honokiol

Blocks NF-κB activation; also anti-inflammatory and antioxidant

Sulfasalazine

Inhibitor of NF-κB activation; also inhibits SXC

C-DIM 12

Nurr1 activator; inhibits NF-κB-dependent gene expression

IT 901

NF-κB c-Rel subunit inhibitor

Zoledronic Acid

Potent farnesyl diphosphate (FPP) synthase inhibitor

FPS ZM1

High affinity antagonist of RAGE

10Z-Hymenialdisine

Pan kinase inhibitor; potently inhibits MEK1

Piceatannol

Inhibits TNF-induced NF-κB activation

Ro 106-9920

Inhibitor of NF-κB activation

PR 39 (porcine)

IκBα inhibitor

Cardamonin

Inhibitor of NF-κB activation; anti-inflammatory

IMD 0354

Inhibitor of IKKβ

Gliotoxin

Inhibitor of 20S proteasome; immunosuppressant

Withaferin A

Inhibits NF-κB activation

SC 514

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Pristimerin

Potent, reversible MAGL inhibitor

PSI

Proteasome inhibitor. Also prevents activation of NF-κB

PF 184

Potent and selective IKKβ inhibitor

CID 2858522

Selectively inhibits PKC-induced NF-κB activation

ML 130

Inhibits NOD1-induced NF-κB activation

Tanshinone IIA

Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties

Andrographolide

Inhibits NFκB; blocks androgen receptor (AR) expression

BMS 345541

Selective allosteric inhibitor of IKK; anti-inflammatory

ML 120B dihydrochloride

Novel IKK2-selective inhibitor

SP 100030

NF-κB and AP-1 dual inhibitor

IP7e

Potent Nurr1 activator

BI 605906

Selective IKKβ inhibitor

GSK 319347A

Potent and selective IKKε inhibitor

CDDO-Me

Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
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