NFkB/IkB Inhibitors: Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes.

"NFkB/IkB Inhibitors" has 34 results in Products.
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MG 132 

Proteasome and calpain inhibitor. Inhibits NF-κB activation

TPCA-1 

Potent, selective inhibitor of IKKβ

Zoledronic Acid 

Potent farnesyl diphosphate (FPP) synthase inhibitor

RAGE antagonist peptide 

RAGE antagonist

Bay 11-7085 

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Bay 11-7821 

E2 ubiquitin (Ub) conjugating enzymes inhibitor

IKK 16 

Selective inhibitor of IKK

IMD 0354 

Inhibitor of IKKβ; also exhibits antibacterial activity

Caffeic acid phenethyl ester 

Specific inhibitor of NF-κB activation

Withaferin A 

Inhibits NF-κB activation

Celastrol 

Inhibits TNF-α-induced NF-κB activation

Triptolide 

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

PF 184 

Potent and selective IKKβ inhibitor

ACHP 

Selective IKKα and IKKβ inhibitor

Amlexanox 

Selective inhibitor of TBK

Sulfasalazine 

Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1

Bengamide B 

Potent inhibitor of NF-κB activation

SP 100030 

NF-κB and AP-1 dual inhibitor

CDDO-Me 

Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ

Piceatannol 

Inhibits TNF-induced NF-κB activation

Arctigenin 

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

Cardamonin 

Inhibitor of NF-κB activation; anti-inflammatory

Luteolin 

Anti-inflammatory, antioxidant and free radical scavenger

SC 514 

IKKβ inhibitor; attenuates NF-κB-induced gene expression

ML 130 

Inhibits NOD1-induced NF-κB activation

Honokiol 

Blocks NF-κB activation; also anti-inflammatory and antioxidant

BMS 345541 

Selective allosteric inhibitor of IKK; anti-inflammatory

ML 120B dihydrochloride 

Novel IKK2-selective inhibitor

IP7e 

Potent Nurr1 activator

BI 605906 

Selective IKKβ inhibitor

GSK 319347A 

Potent and selective IKKε inhibitor

C-DIM 12 

Nurr1 activator; inhibits NF-κB-dependent gene expression

FPS ZM1 

High affinity antagonist of RAGE

(R)-Shikonin 

PTEN inhibitor; induces necroptosis; anti-inflammatory
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