Human/Mouse/Rat PTP gamma /PTPRG Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB4608G Datasheet / COA / SDS

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FAB4608G-100UG

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Human/Mouse/Rat PTP gamma /PTPRG Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat PTP gamma /PTPRG in Western blots. In Western blots, no cross-reactivity with recombinant human PTPRM, PTPRK, PTPRS, LAR, or DEP1 is observed.

Source

Monoclonal Mouse IgG2b Clone # 481505

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PTPÎ³/PTPRG
Ser111-Ala541
Accession # P23470

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PTP gamma/PTPRG

Protein Tyrosine Phosphatase, Receptor type gamma (PTPR gamma ), also called PTPRG and PTPG, is a transmembrane protein. Its extracellular region contains carbonic anhydrase fibronectin III domains, suggesting that it interacts with adhesion molecules, but the only reported activator is an intracellular ATP-dependent factor. During brain development, PTPR gamma is found exclusively in post-mitotic neurons. A wide variety of cancers, including colon, renal clear cell, lung, breast, and cervical cancers, show a high incidence of defects in the PTPR gamma gene, suggesting the protein has a key regulatory function in tumor suppression.

Long Name

Protein Tyrosine Phosphatase Receptor-type Gamma

Entrez Gene IDs

5793 (Human); 19270 (Mouse); 171357 (Rat)

Alternate Names

EC 3.1.3.48; H_RG317H01.1; HPTPG; protein tyrosine phosphatase, receptor type, G; protein tyrosine phosphatase, receptor type, gamma polypeptide; Protein-tyrosine phosphatase gamma; PTP gamma; PTPG; PTPGprotein tyrosine phosphatase gamma; PTPRG; receptor type protein tyrosine phosphatase gamma; receptor tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor-type tyrosine-protein phosphatase gamma; RPTPG; R-PTP-GAMMA