Naloxone 3-glucuronide carbonic acid salt
Discontinued Product
Chemical Name: (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt
Purity: ≥98%
Biological Activity
Naloxone 3-glucuronide carbonic acid salt is a Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
Simpkins et al.
J.Pharmacol.Exp.Ther., 1988;244:195
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