Naloxone hydrochloride

  ( 27 citations )    
Product Datasheet
Catalog Number:0599
Chemical Name:(5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
Product Details
Citations (27)
Reviews
Biological Activity
Opioid antagonist.
Technical Data
  • M.Wt:
    363.84
  • Formula:
    C19H21NO4.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    357-08-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Naloxone hydrochloride include:

27 Citations: Showing 1 - 10
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  1. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
    Authors: Levoye Et al.
    PLoS One  2015;6:167
  2. Hypothalamic POMC neurons promote cannabinoid-induced feeding.
    Authors: Koch Et al.
    J Neurosci  2015;519:45
  3. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  4. Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain.
    Authors: Navratilova Et al.
    Front Endocrinol (Lausanne)  2015;35:7264
  5. The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
    Authors: Kelly Et al.
    World J Gastroenterol  2015;232:305
  6. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci  2015;22:79
  7. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    PLoS One  2015;22:49
  8. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    Nature  2015;19:2587
  9. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Psychopharmacology (Berl)  2015;10:e0145556
  10. Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human.
    Authors: Pereira Et al.
    Proc Natl Acad Sci U S A  2015;10:e0134441
  11. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
    Authors: Chen Et al.
    Neuropsychopharmacology  2014;20:1298
  12. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    J Biomed Sci  2013;38:1296
  13. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
    Authors: Largent-Milnes Et al.
    J Pharmacol Exp Ther  2013;347:7
  14. Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
    Authors: Moser and Giesler
    J Neurosci  2013;33:6093
  15. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem  2013;288:36703
  16. Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.
    Authors: Marti Et al.
    Br J Pharmacol  2013;168:863
  17. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
    Authors: Navratilova Et al.
    FASEB J  2012;109:20709
  18. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol  2011;105:1051
  19. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    Authors: Gross Et al.
    Am J Physiol Heart Circ Physiol  2010;298:H2201
  20. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
    Authors: Largent-Milnes Et al.
    Br J Pharmacol  2010;161:986
  21. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A  2009;2011:159209
  22. Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.
    Authors: Cruz Et al.
    J Neurosci  2008;28:4069
  23. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    J Cell Mol Med  2007;32:399
  24. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1.
    Authors: Patel Et al.
    Nat Commun  2007;21:1565
  25. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591
  26. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci  2004;24:4530
  27. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    Neuropsychopharmacology  2003;100:14397
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