Naloxone hydrochloride

Catalog # Availability Size / Price Qty
Naloxone hydrochloride | CAS No. 357-08-4 | Miscellaneous/Non-selective Opioid Antagonists
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Description: Non-selective opioid antagonist

Chemical Name: (5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride

Purity: ≥99%

Product Details
Citations (32)
Supplemental Products

Biological Activity

Naloxone hydrochloride is an opioid antagonist.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

  1. Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity.
    Spivak et al.
    Mol.Pharmacol., 1997;52:983
  2. Endogenous opiates: 1995.
    Olson et al.
    Peptides, 1996;17:1421
  3. Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with mor. and injected with naloxone, in the absence or presence of the antiabstinence agent clon.
    Pinelli and Trivulzio
    J.Pharmacol.Toxicol.Methods, 1997;38:117

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Citations for Naloxone hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Naloxone hydrochloride include:

32 Citations: Showing 1 - 10

  1. A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
    Authors: Pedersen Et al.
    J Biol Chem  2021;296:100503
  2. Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
    Authors: Wang Et al.
    Neuron  2018;98:90
  3. Pharmacogenomics of GPCR Drug Targets.
    Authors: Hauser Et al.
    Cell  2018;172:41
  4. Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake.
    Authors: Jeong Et al.
    PLoS Biol  2018;16:e2004399
  5. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins.
    Authors: Francois Et al.
    Neuron  2017;93:822
  6. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
    Authors: Levoye Et al.
    PLoS One  2015;6:167
  7. Hypothalamic POMC neurons promote cannabinoid-induced feeding.
    Authors: Koch Et al.
    J Neurosci  2015;519:45
  8. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  9. Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain.
    Authors: Navratilova Et al.
    Front Endocrinol (Lausanne)  2015;35:7264
  10. The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
    Authors: Kelly Et al.
    World J Gastroenterol  2015;232:305
  11. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci  2015;22:79
  12. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    PLoS One  2015;22:49
  13. Bupren.-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    Nature  2015;19:2587
  14. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Psychopharmacology (Berl)  2015;10:e0145556
  15. Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human.
    Authors: Pereira Et al.
    Proc Natl Acad Sci U S A  2015;10:e0134441
  16. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
    Authors: Chen Et al.
    Neuropsychopharmacology  2014;20:1298
  17. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    J Biomed Sci  2013;38:1296
  18. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
    Authors: Largent-Milnes Et al.
    J Pharmacol Exp Ther  2013;347:7
  19. Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
    Authors: Moser and Giesler
    J Neurosci  2013;33:6093
  20. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem  2013;288:36703
  21. Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.
    Authors: Marti Et al.
    Br J Pharmacol  2013;168:863
  22. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
    Authors: Navratilova Et al.
    FASEB J  2012;109:20709
  23. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol  2011;105:1051
  24. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    Authors: Gross Et al.
    Am J Physiol Heart Circ Physiol  2010;298:H2201
  25. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
    Authors: Largent-Milnes Et al.
    Br J Pharmacol  2010;161:986
  26. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A  2009;2011:159209
  27. Absence and rescue of mor. withdrawal in GIRK/Kir3 knock-out mice.
    Authors: Cruz Et al.
    J Neurosci  2008;28:4069
  28. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    J Cell Mol Med  2007;32:399
  29. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1.
    Authors: Patel Et al.
    Nat Commun  2007;21:1565
  30. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591
  31. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci  2004;24:4530
  32. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    Neuropsychopharmacology  2003;100:14397


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