Catalog Number: 0599
Chemical Name: (5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
Biological Activity
Opioid antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity.
    Spivak et al.
    Mol.Pharmacol., 1997;52:983
  3. Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.
    Pinelli and Trivulzio
    J.Pharmacol.Toxicol.Methods, 1997;38:117

The citations listed below are publications that use Tocris products. Selected citations for Naloxone hydrochloride include:

24 Citations: Showing 1 - 10
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  1. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
    Authors: Levoye Et al.
    PLoS One 2015;6:167
  2. Hypothalamic POMC neurons promote cannabinoid-induced feeding.
    Authors: Koch Et al.
    J Neurosci 2015;519:45
  3. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  4. Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain.
    Authors: Navratilova Et al.
    Front Endocrinol (Lausanne) 2015;35:7264
  5. The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
    Authors: Kelly Et al.
    World J Gastroenterol 2015;232:305
  6. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci 2015;22:79
  7. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    PLoS One 2015;22:49
  8. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    Nature 2015;19:2587
  9. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Psychopharmacology (Berl) 2015;10:e0145556
  10. Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human.
    Authors: Pereira Et al.
    Proc Natl Acad Sci U S A 2015;10:e0134441
  11. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
    Authors: Chen Et al.
    Neuropsychopharmacology 2014;20:1298
  12. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    J Biomed Sci 2013;38:1296
  13. Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
    Authors: Moser and Giesler
    J Neurosci 2013;33:6093
  14. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem 2013;288:36703
  15. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
    Authors: Navratilova Et al.
    FASEB J 2012;109:20709
  16. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol 2011;105:1051
  17. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
    Authors: Largent-Milnes Et al.
    Br J Pharmacol 2010;161:986
  18. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A 2009;2011:159209
  19. Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.
    Authors: Cruz Et al.
    J Neurosci 2008;28:4069
  20. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    J Cell Mol Med 2007;32:399
  21. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1.
    Authors: Patel Et al.
    Nat Commun 2007;21:1565
  22. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol 2006;16:1591
  23. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci 2004;24:4530
  24. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    Neuropsychopharmacology 2003;100:14397
Expand to show all 24 Citations

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