Spaglumic acid
Chemical Name: N-Acetyl-L-aspartyl-L-glutamic acid
Purity: ≥96%
Biological Activity
The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system.
Neale et al.
J.Neurochem., 2000;75:443 -
N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.
Wroblewska et al.
J.Neurochem., 1997;69:174 -
N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.
Thomas et al.
J.Pharmacol.Exp.Ther., 2000;295:16
Product Datasheets
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Citations for Spaglumic acid
The citations listed below are publications that use Tocris products. Selected citations for Spaglumic acid include:
2 Citations: Showing 1 - 2
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Authors: Scholler
Nat Chem Biol 2017;13(4):372
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The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.
Authors: Kolodziejczyk Et al.
Brain 2009;132:1496
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