(±)-threo-3-Methylglutamic acid
Discontinued Product
Purity: ≥98%
Biological Activity
(±)-threo-3-Methylglutamic acid is a potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems.
Eliasof et al.
J.Neurochem., 2001;77:550 -
Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2.
Mitrovic et al.
J.Biol.Chem., 1998;273:14698 -
Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2.
Vandenberg et al.
Mol.Pharmacol., 1997;51:809
Product Datasheets
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Citation for (±)-threo-3-Methylglutamic acid
The citations listed below are publications that use Tocris products. Selected citations for (±)-threo-3-Methylglutamic acid include:
1 Citation: Showing 1 - 1
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Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability.
Authors: Jarzylo and Man
J Neurosci 2012;32:2552
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