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VU 0483605

Catalog #: 5377
1 Citation Datasheet / COA / SDS

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VU 0483605 | CAS No. 1623101-11-0 | Group I mGluR Modulators
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Description: Positive allosteric modulator of mGlu1 receptors

Chemical Name: 3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Positive allosteric modulator at mGlu1 (EC50 values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1 over mGlu4. Potentiates the decreased glutamate-induced calcium response in mGlu1 mutant cell models of schizophrenia.

Technical Data

M.Wt:
446.67
Formula:
C20H10Cl3N3O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1623101-11-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for VU 0483605

The citations listed below are publications that use Tocris products. Selected citations for VU 0483605 include:

1 Citation: Showing 1 - 1

  1. "Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
    Authors: Hellyer Et al.
    Mol.Pharmacol.  2018;93:504

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