Chemical Name: (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
Biological ActivityWithaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Withaferin A is a potent inhibitor of angiogenesis.
Mohan et al.
The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry".
Yang et al.
Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity.
Kaileh et al.
Citations for Withaferin A
The citations listed below are publications that use Tocris products. Selected citations for Withaferin A include:
7 Citations: Showing 1 - 7
Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis.
Authors: Andersson Et al.
JCI Insight 2018;3
The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
Authors: Ryals Et al.
Front Cell Neurosci 2018;12:445
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
Authors: Yang Et al.
Neural Plast 2016;7:11385
Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.
Authors: Hatzold Et al.
Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes.
Authors: Martorana Et al.
EMBO J 2015;2015:381964
TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of AVNA.
Authors: Trendelenburg Et al.
Skelet Muscle 2012;2:3
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Authors: Yadav Et al.
J Mol Med (Berl) 2010;88:1243
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