Withaferin A

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Withaferin A | CAS No. 5119-48-2 | NFkB/IkB Inhibitors
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Description: Inhibits NF-κB activation

Chemical Name: (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone

Purity: ≥98%

Product Details
Citations (7)

Biological Activity

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.

Technical Data

Soluble to 10 mM in DMSO
Store at -20°C

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Tocris products are intended for laboratory research use only, unless stated otherwise.

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