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Cantharidin

Catalog #: 1548
5 Citations Datasheet / COA / SDS

Discontinued Product

1548 has been discontinued.
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Cantharidin | CAS No. 56-25-7 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Protein phosphatase 1 and 2A inhibitor

Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cantharidin is a natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.

Technical Data

M.Wt:
196.2
Formula:
C10H12O4
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
56-25-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
    Egbert J, Shuhaibar L, Edmund A, Van Helden D, Robinson J, Uliasz T, Baena V, Geerts A, Wunder F, Potter L, Jaffe L
    Development, 2014;141(18):3594-604.
  2. Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes
    C Lang, KR Campbell, BJ Ryan, P Carling, M Attar, J Vowles, OV Perestenko, R Bowden, F Baig, M Kasten, MT Hu, SA Cowley, C Webber, R Wade-Marti
    Cell Stem Cell, 2018;0(0):.
  3. Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice.
    Eldridge and Casida
    Toxicol.Appl.Pharmacol., 1995;130:95
  4. Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A.
    Honkanen
    FEBS Lett., 1993;330:283
  5. The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability.
    Knapp et al.
    J.Pharmacol.Exp.Ther., 1999;289:1480

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Citations for Cantharidin

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