Chemical Name: 9,10-Deepithio-9,10-didehydroacanthifolicin
Biological ActivityPotent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Okadaic acid: a new probe for the study of cellular regulation.
Cohen et al.
Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism.
Haystead et al.
Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies.
McCluskey et al.
Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes.
Standaert et al.
Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt.
Nuydens et al.
Citations for Okadaic acid
The citations listed below are publications that use Tocris products. Selected citations for Okadaic acid include:
28 Citations: Showing 1 - 10
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Authors: Messal Et al.
The insect, Galleria mellonella, is a compatible model for evaluating the toxicology of okadaic acid.
Authors: Coates Et al.
Cell Biol Toxicol 2019;35:219
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Authors: Chiu Et al.
Cell Rep 2019;28:332
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Authors: Livingstone Et al.
Front Mol Neurosci 2019;12:198
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
Authors: Jones Et al.
Sci Signal 2018;11
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Authors: Pose-Utrilla Et al.
Nat Commun 2017;8:2275
Selective inhibition of the kinase DYRK1A by targeting its folding process.
Authors: Kii Et al.
Nat Commun 2016;7:11391
Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.
Authors: Bartley Et al.
Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
Authors: Cohen Et al.
Neurobiol Dis 2015;460:88
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
Biochem Biophys Res Commun 2015;2
Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
Authors: Hullinger Et al.
Neurobiol Learn Mem 2015;125:126
IKKα negatively regulates ASC-dependent inflammasome activation.
Authors: Martin Et al.
Nat Commun 2014;5:4977
Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
Authors: Chen Et al.
J Neurosci 2014;34:9621
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
J Neurosci 2013;8:e66404
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Authors: Bernard Et al.
PLoS One 2013;59:42736
Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.
Authors: Brito Et al.
Cell Death Dis 2013;4:e595
TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
Authors: Pribiag and Stellwagen
Mol Pain 2013;33:15879
Lipid rafts contribute to agonist-induced serine/threonine phosphatase activation and platelet aggregation.
Authors: Pradhan and Vijayan
J Neurosci 2013;11:1612
Increased neuronal activity fragments the Golgi complex.
Authors: Thayer Et al.
Proc Natl Acad Sci U S A 2013;110:1482
Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Authors: Rankovic Et al.
PLoS One 2011;6:e27474
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
Authors: Li and Burrell
Learn Mem 2011;18:545
DA-dependent tuning of striatal inhibitory synaptogenesis.
Authors: Goffin Et al.
J Neurosci 2010;30:2935
Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II.
Authors: Bodhinathan Et al.
J Neurosci 2010;30:1914
Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
Authors: Li Et al.
A phosphatase cascade by which rewarding stimuli control nucleosomal response.
Authors: Stipanovich Et al.
Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
Authors: Kim Et al.
J Thromb Haemost 2008;105:4429
NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
Authors: Marsden Et al.
J Neurosci 2007;27:14326
Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1.
Authors: Dart and Leyland
J Biol Chem 2001;276:20499
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Reviews for Okadaic acid
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HL-1 cardiomyocytes were treated with 100 nM fostriecin, 100 nM Okadaic acid or 50 nM 8-bromo-cAMP for 30 min followed by Western blot analysis for pCaMKII expression. Okadaic acid significantly increased phosphorylation of CaMKII; indicating a major role of PP1 in CaMKII dephosphorylation.