Catalog Number: 1136
Chemical Name: 9,10-Deepithio-9,10-didehydroacanthifolicin
Biological Activity
Potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.
Technical Data
  • M.Wt:
    805.01
  • Formula:
    C44H68O13
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    78111-17-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism.
    Haystead et al.
    Nature, 1989;337:78
  3. Okadaic acid: a new probe for the study of cellular regulation.
    Cohen et al.
    TiBS, 1990;15:98
  4. Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies.
    McCluskey et al.
    J.Med.Chem., 2002;45:1151
  5. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt.
    Nuydens et al.
    J.Neurochem., 1998;70:1124
  6. Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes.
    Standaert et al.
    J.Biol.Chem., 1999;274:14074
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Okadaic acid include:

15 Citations: Showing 1 - 10
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  1. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
    Authors: Cohen Et al.
    Neurobiol Dis 2015;460:88
  2. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    Biochem Biophys Res Commun 2015;2
  3. IKKα negatively regulates ASC-dependent inflammasome activation.
    Authors: Martin Et al.
    Nat Commun 2014;5:4977
  4. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    J Neurosci 2013;8:e66404
  5. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    PLoS One 2013;59:42736
  6. Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.
    Authors: Brito Et al.
    Cell Death Dis 2013;4:e595
  7. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    Mol Pain 2013;33:15879
  8. Lipid rafts contribute to agonist-induced serine/threonine phosphatase activation and platelet aggregation.
    Authors: Pradhan and Vijayan
    J Neurosci 2013;11:1612
  9. Increased neuronal activity fragments the Golgi complex.
    Authors: Thayer Et al.
    Proc Natl Acad Sci U S A 2013;110:1482
  10. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One 2011;6:e27474
  11. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem 2011;18:545
  12. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    J Neurosci 2010;30:2935
  13. Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
    Authors: Li Et al.
    Eneuro 2009;29:15551
  14. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
    Authors: Kim Et al.
    J Thromb Haemost 2008;105:4429
  15. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1.
    Authors: Dart and Leyland
    J Biol Chem 2001;276:20499
Expand to show all 15 Citations

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