Okadaic acid

  ( 20 citations )    
Product Datasheet
Catalog Number:1136
Chemical Name:9,10-Deepithio-9,10-didehydroacanthifolicin
Product Details
Citations (20)
Reviews
Biological Activity
Potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.
Technical Data
  • M.Wt:
    805.01
  • Formula:
    C44H68O13
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    78111-17-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Okadaic acid include:

20 Citations: Showing 1 - 10
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  1. Selective inhibition of the kinase DYRK1A by targeting its folding process.
    Authors: Kii Et al.
    Nat Commun  2016;7:11391
  2. Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.
    Authors: Bartley Et al.
    Eneuro  2016;3
  3. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
    Authors: Cohen Et al.
    Neurobiol Dis  2015;460:88
  4. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    Biochem Biophys Res Commun  2015;2
  5. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
    Authors: Hullinger Et al.
    Neurobiol Learn Mem  2015;125:126
  6. IKKα negatively regulates ASC-dependent inflammasome activation.
    Authors: Martin Et al.
    Nat Commun  2014;5:4977
  7. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    J Neurosci  2013;8:e66404
  8. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    PLoS One  2013;59:42736
  9. Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.
    Authors: Brito Et al.
    Cell Death Dis  2013;4:e595
  10. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    Mol Pain  2013;33:15879
  11. Lipid rafts contribute to agonist-induced serine/threonine phosphatase activation and platelet aggregation.
    Authors: Pradhan and Vijayan
    J Neurosci  2013;11:1612
  12. Increased neuronal activity fragments the Golgi complex.
    Authors: Thayer Et al.
    Proc Natl Acad Sci U S A  2013;110:1482
  13. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  14. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  15. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    J Neurosci  2010;30:2935
  16. Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
    Authors: Li Et al.
    Eneuro  2009;29:15551
  17. A phosphatase cascade by which rewarding stimuli control nucleosomal response.
    Authors: Stipanovich Et al.
    Nature  2008;453:879
  18. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
    Authors: Kim Et al.
    J Thromb Haemost  2008;105:4429
  19. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
    Authors: Marsden Et al.
    J Neurosci  2007;27:14326
  20. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1.
    Authors: Dart and Leyland
    J Biol Chem  2001;276:20499
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