Okadaic acid

Catalog # Availability Size / Price Qty
1136/25U
Okadaic acid | CAS No. 78111-17-8 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Protein phosphatase 1 and 2A inhibitor

Chemical Name: 9,10-Deepithio-9,10-didehydroacanthifolicin

Product Details
Citations (28)
Reviews (2)

Biological Activity

Potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.

Technical Data

M.Wt:
805.01
Formula:
C44H68O13
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
78111-17-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Okadaic acid

The citations listed below are publications that use Tocris products. Selected citations for Okadaic acid include:

28 Citations: Showing 1 - 10

  1. Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
    Authors: Messal Et al.
     2019;566:126
  2. The insect, Galleria mellonella, is a compatible model for evaluating the toxicology of okadaic acid.
    Authors: Coates Et al.
    Cell Biol Toxicol  2019;35:219
  3. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
    Authors: Chiu Et al.
    Cell Rep  2019;28:332
  4. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
    Authors: Livingstone Et al.
    Front Mol Neurosci  2019;12:198
  5. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
    Authors: Jones Et al.
    Sci Signal  2018;11
  6. Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
    Authors: Pose-Utrilla Et al.
    Nat Commun  2017;8:2275
  7. Selective inhibition of the kinase DYRK1A by targeting its folding process.
    Authors: Kii Et al.
    Nat Commun  2016;7:11391
  8. Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.
    Authors: Bartley Et al.
    Eneuro  2016;3
  9. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
    Authors: Cohen Et al.
    Neurobiol Dis  2015;460:88
  10. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    Biochem Biophys Res Commun  2015;2
  11. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
    Authors: Hullinger Et al.
    Neurobiol Learn Mem  2015;125:126
  12. IKKα negatively regulates ASC-dependent inflammasome activation.
    Authors: Martin Et al.
    Nat Commun  2014;5:4977
  13. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
    Authors: Chen Et al.
    J Neurosci  2014;34:9621
  14. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    J Neurosci  2013;8:e66404
  15. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    PLoS One  2013;59:42736
  16. Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.
    Authors: Brito Et al.
    Cell Death Dis  2013;4:e595
  17. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    Mol Pain  2013;33:15879
  18. Lipid rafts contribute to agonist-induced serine/threonine phosphatase activation and platelet aggregation.
    Authors: Pradhan and Vijayan
    J Neurosci  2013;11:1612
  19. Increased neuronal activity fragments the Golgi complex.
    Authors: Thayer Et al.
    Proc Natl Acad Sci U S A  2013;110:1482
  20. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  21. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  22. DA-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    J Neurosci  2010;30:2935
  23. Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II.
    Authors: Bodhinathan Et al.
    J Neurosci  2010;30:1914
  24. Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
    Authors: Li Et al.
    Eneuro  2009;29:15551
  25. A phosphatase cascade by which rewarding stimuli control nucleosomal response.
    Authors: Stipanovich Et al.
    Nature  2008;453:879
  26. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
    Authors: Kim Et al.
    J Thromb Haemost  2008;105:4429
  27. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
    Authors: Marsden Et al.
    J Neurosci  2007;27:14326
  28. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1.
    Authors: Dart and Leyland
    J Biol Chem  2001;276:20499

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Works as intended.
By Anonymous on 04/04/2020
Application: Species: Rat

Okadaic acid for PP2A at 20 nM

PMID: 31291571 Reference

Okadaic acid increases phosphorylation of CaMKII in HL-1 cells
By Anonymous on 05/15/2019
Application: Species: Mouse

HL-1 cardiomyocytes were treated with 100 nM fostriecin, 100 nM Okadaic acid or 50 nM 8-bromo-cAMP for 30 min followed by Western blot analysis for pCaMKII expression. Okadaic acid significantly increased phosphorylation of CaMKII; indicating a major role of PP1 in CaMKII dephosphorylation.


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