Potent inhibitor of protein phosphatase 1 (IC50
= 3 nM) and protein phosphatase 2A (IC50
= 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism.
Haystead et al.
Okadaic acid: a new probe for the study of cellular regulation.
Cohen et al.
Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies.
McCluskey et al.
Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt.
Nuydens et al.
Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes.
Standaert et al.
The citations listed below are publications that use Tocris products. Selected citations for Okadaic acid include:
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