Nω-Propyl-L-arginine hydrochloride
Chemical Name: N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride
Purity: ≥98%
Biological Activity
Nω-Propyl-L-arginine hydrochloride is a highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices.
He L, Linden D, Sapirstein A
PLoS ONE, 2102;7(8):e42194. -
The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.
Kakoki et al.
Am.J.Physiol.Regul.Integr.Comp.Physiol., 2001;281:R91 -
Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine.
Zhang et al.
J.Med.Chem., 1997;40:3869
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Citations for Nω-Propyl-L-arginine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Nω-Propyl-L-arginine hydrochloride include:
4 Citations: Showing 1 - 4
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Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.
Authors: Xu Et al.
Sci Transl Med 2016;8:333ra48
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Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats.
Authors: Lu Et al.
Diabetes 2015;10:e0140762
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Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Authors: Mathison Et al.
Br J Pharmacol 2004;142:1247
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Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.
Authors: Slesinger
Biophys J 2001;80:707
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