ARL 17477 dihydrochloride
Chemical Name: N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride
Biological ActivityARL 17477 dihydrochloride is a selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC50 values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.
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Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia.
Hicks et al.
ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia.
O'Neill et al.
Brain Res., 2000;871:234
ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats.
Zhang et al.
J.Cereb.Flow Metab., 1996;16:599
Citation for ARL 17477 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ARL 17477 dihydrochloride include:
1 Citation: Showing 1 - 1
Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase.
Authors: Grekov Et al.
Biomed Res Int 2017;2017:1309485
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