ARL 17477 dihydrochloride

Catalog # Availability Size / Price Qty
3319/10
3319/50
ARL 17477 dihydrochloride | CAS No. 866914-87-6 | nNOS Inhibitors
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Description: Selective nNOS inhibitor

Chemical Name: N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC50 values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.

Technical Data

M.Wt:
442.83
Formula:
C20H20ClN3S.2HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
866914-87-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Background References

  1. Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia.
    Hicks et al.
    Eur.J.Pharmacol., 1999;381:113
  2. ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia.
    O'Neill et al.
    Brain Res., 2000;871:234
  3. ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats.
    Zhang et al.
    J.Cereb.Flow Metab., 1996;16:599

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Citation for ARL 17477 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ARL 17477 dihydrochloride include:

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