Vascular Endothelial Growth Factor (VEGF) family members are potent mitogenic and angiogenic proteins with critical physiological roles in development and wound healing. In addition, they are also centrally involved in promoting tumor growth and vascular disease. Members of the VEGF gene family include VEGF/VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and Placental Growth Factor (PlGF). Alternative splicing of VEGF, VEGF-B, and PlGF can generate multiple isoforms with different biological properties. These isoforms include VEGF110, VEGF121, VEGF145, VEGF148, VEGF162, VEGF165, VEGF183, VEGF189, VEGF206, VEGF-B167, VEGF-B187, PlGF-1, PlGF-2, PlGF-3, and PlGF-4. VEGFs homodimerize and transduce intracellular signals by binding to VEGF receptors (VEGF R1, VEGF R2, and VEGF R3) and Neuropilins, which are localized to the cell surface and have a unique specificity for different VEGF isoforms. Ligand binding promotes receptor dimerization, autophosphorylation, and activation of multiple downstream signaling cascades that stimulate vascular permeability, cell survival, proliferation, migration, or adhesion.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.