279 results for "ALK/CD246" in 产品
ALK/CD246 Products
Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
| Reactivity: | Human |
| Reactivity: | Human |
| Source: | NS0 |
| Accession #: | Q9UM73.3 |
| Applications: | Bioactivity |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | IHC, WB, Simple Western |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #7A11A4 |
| Applications: | WB, ELISA, Flow, ICC/IF |
![Western Blot: ALK/CD246 Antibody (7A11A4)BSA Free [NBP2-61845]](https://resources.rndsystems.com/images/products/ALK-CD246-Antibody-7A11A4-Western-Blot-NBP2-61845-img0004.jpg "Western Blot: ALK/CD246 Antibody (7A11A4)BSA Free [NBP2-61845]")
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #383625 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #383603 |
| Applications: | ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #ALK/1504 |
| Applications: | IHC, Flow, ICC/IF |
![Immunohistochemistry-Paraffin: ALK/CD246 Antibody (ALK/1504) [NBP3-07771]](https://resources.rndsystems.com/images/products/ALK-CD246-Antibody-ALK-1504-Immunohistochemistry-Paraffin-NBP3-07771-img0002.jpg "Immunohistochemistry-Paraffin: ALK/CD246 Antibody (ALK/1504) [NBP3-07771]")
Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
| Chemical Name: | 2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide |
| Purity: | ≥98% |
Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
| Chemical Name: | N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine |
| Purity: | ≥98% |
Selective ALK Degrader (PROTAC®)
| Chemical Name: | N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide |
| Purity: | ≥98% |
Selective ALK Degrader (PROTAC®)
| Chemical Name: | N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide |
| Purity: | ≥98% |
Negative control for TL 13-112 (Cat. No. 6745)
| Chemical Name: | N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide |
| Purity: | ≥98% |
Negative control for TL 13-12 (Cat. No. 6744)
| Chemical Name: | N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide |
| Purity: | ≥98% |
Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
| Alternate Names: | LDK378 |
| Chemical Name: | 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine |
| Purity: | ≥98% |
Potent and selective ALK2 inhibitor
| Chemical Name: | 1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride |
| Purity: | ≥98% |
| Reactivity: | Human |
| Reactivity: | Mouse |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #RM361 |
| Applications: | IHC, WB |
![Western Blot: ALK/CD246 Antibody (RM361) [NBP2-77424]](https://resources.rndsystems.com/images/products/ALK-CD246-Antibody-RM361-Western-Blot-NBP2-77424-img0003.jpg "Western Blot: ALK/CD246 Antibody (RM361) [NBP2-77424]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: ALK/CD246 Antibody [NBP2-48518]](https://resources.rndsystems.com/images/products/ALK-CD246-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-48518-img0002.jpg "Immunocytochemistry/ Immunofluorescence: ALK/CD246 Antibody [NBP2-48518]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #ALK1/6698R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #ALK1/6698R |
| Applications: | IHC |
Potent and selective ALK1/2 inhibitor. Brain-penetrant
| Chemical Name: | 6-(4-Piperazin-1-ylphenyl)-3-quinolin-4-ylfuro[3,2-b]pyridine trihydrochloride |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #ALK/1503 |
| Applications: | WB, Flow, ICC/IF |
![Western Blot: ALK/CD246 Antibody (ALK/1503) [NBP2-53253]](https://resources.rndsystems.com/images/products/ALK-CD246-Antibody-ALK-1503-Western-Blot-NBP2-53253-img0002.jpg "Western Blot: ALK/CD246 Antibody (ALK/1503) [NBP2-53253]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #ALK1/7008R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #ALK1/7008R |
| Applications: | IHC |
