Chemical Name: N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide
Biological ActivityTL 13-112 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h.
Negative control TL 13-110 (Cat. No. 6746) also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemically induced degradation of anaplastic lymphoma kinase (ALK).
Powell et al.
Citations for TL 13-112
The citations listed below are publications that use Tocris products. Selected citations for TL 13-112 include:
3 Citations: Showing 1 - 3
Engineered PROTAC-CID systems for mammalian inducible gene regulation.
Authors: Ma Et al.
J Am Chem Soc 2023;145:1593
Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma.
Authors: Martina Et al.
Front Oncol 2023;12:1085672
Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma.
Authors: Cinzia Et al.
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