Proteome Profiler Human Phospho-RTK Array Kit

Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
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Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line.
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Proteome Profiler Human Phospho-RTK Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative phosphorylation of human receptor tyrosine kinases. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 49 human receptor tyrosine kinases simultaneously
  • Requires no specialized equipment


Principle of the Assay

The Proteome Profiler Human Phospho-RTK Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Tyrosine phosphorylation of the captured proteins is detected with an HRP-conjugated pan phospho-tyrosine antibody (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple receptors in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Lysis Buffer
  • Wash Buffer
  • Anti-Phospho-Tyrosine-HRP Detection Antibody
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

Simultaneously detect the relative phosphorylation of these RTKs in a single sample
ALK/CD246 EphB4 MuSK
Axl EphB6 PDGF R alpha
DDR1 ErbB2 PDGF R beta
DDR2 ErbB3 c-Ret
Dtk ErbB4 ROR1
EphA1 FGF R2 alpha Ryk
EphA2 FGF R3 SCF R/c-kit
EphA3 FGF R4 Tie-1
EphA4 Flt-3/Flk-2 Tie-2
EphA5 HGF R/c-MET TrkA
EphA6 IGF-I R TrkB
EphA7 Insulin R/CD220 TrkC
EphA10 M-CSF R VEGF R1/Flt-1
EphB2 MSP R/Ron VEGF R3/Flt-4

Assays for Analytes represented in the Proteome Profiler Human Phospho-RTK Array Kit

Analyte Quantikine® ELISA Kits DuoSet® ELISA Development System DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA Kits
Axl   DY154 DYC1643    
DDR1     DYC2396 DYC5859  
DDR2     DYC2538 DYC6170  
Dtk   DY859      
EGF R DEGFR0 DY231 DYC1854 DYC1095B  
EphA1     DYC638    
EphA2     DYC3035 DYC4056  
EphA4     DYC3038 DYC4057  
EphB4     DYC3038 DYC4057  
ErbB2   DY1129 DYC1129 DYC1768  
ErbB3   DY348 DYC234 DYC1769 KCB5677
ErbB4     DYC1133 DYC2115
FGF R1       DYC5079  
FGF R2 alpha     DYC665 DYC684  
FGF R3     DYC766 DYC2719  
FGF R4     DYC685 DYC5516  
Flt-3/Flk     DYC912 DYC368  
HGF R/c-MET   DY358 DYC358 DYC2480  
IGF-I R   DY391 DYC305 DYC1770  
Insulin R/CD220     DYC1544 DYC2718  
M-CSF R   DY329 DYC329 DYC3268  
Mer   DY6488 DYC891 DYC2579  
MSP R/Ron     DYC691 DYC1947  
PDGF R alpha     DYC322 DYC2114  
PDGF R beta     DYC385 DYC1767  
SCF R/c-kit DSCR00 DY332 DYC332 DYC3527  
Tie-1   DY5907      
Tie-2 DTE200 DY5159   DCY2720  
TrkA     DYC175 DYC2578  
TrkB     DYC397 DYC688  
TrkC     DYC373    
VEGF R1/Flt-1 DVR100B DY321B   DYC4170  
VEGF R2/KDR DVR200 DY357 DYC1780 DYC1766  
VEGF R3/Flt-4   DY349 DYC3491 DYC2724  


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Product Datasheets

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Scientific Data

Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes. Cells for rhFGF acidic/Heparin treatment either received pre-treatment with the reversible FGF R and VEGF R inhibitor PD 173074 (Tocris, Catalog # 3044), or with the FGF R-specific tyrosine kinase inhibitor SU 5402 (Tocris, Catalog # 3300), or no pre-treatment.

The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. MDA-MB-453 human breast cancer cells were treated with 100 ng/mL of rhNRG1-beta1/HRG1-beta1 (R&D Systems, Catalog # 396-HB) for 5 minutes. 5 µg of rhErbB2 (R&D Systems, Catalog # 1129-ER), rhErbB3 (R&D Systems, Catalog # 348-RB), or rhErbB4 (R&D Systems, Catalog # 1131-ER) extracellular domains were added to 50 µg of lysate and analyzed using the Human Phospho-RTK Array. Competition of a particular ErbB receptor was observed only with the corresponding recombinant soluble receptor.

Citations for Proteome Profiler Human Phospho-RTK Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

263 Citations: Showing 1 - 10
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  1. Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
    Authors: Kim, S;Carvajal, R;Kim, M;Yang, HW;
    Cell reports  2023-05-29
  2. Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
    Authors: Pillay, V;Shukla, L;Herle, P;Maciburko, S;Bandara, N;Reid, I;Morgan, S;Yuan, Y;Luu, J;Cowley, KJ;Ramm, S;Simpson, KJ;Achen, MG;Stacker, SA;Shayan, R;Karnezis, T;
    Frontiers in pharmacology  2023-04-28
  3. Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities
    Authors: I Paassen, J Williams, C Ríos Arceo, F Ringnalda, KS Mercer, JL Buhl, N Moreno, A Federico, NE Franke, M Kranendonk, SA Upadhyaya, K Kerl, M van de Wet, H Clevers, M Kool, EW Hoving, MF Roussel, J Drost
    Oncogene, 2023-04-05;0(0):.  2023-04-05
  4. Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema
    Authors: JJ Park, K Oh, GW Lee, G Bang, JH Park, HB Kim, JY Kim, EY Shin, EG Kim
    Experimental & Molecular Medicine, 2023-04-03;0(0):.  2023-04-03
  5. Redundant Signaling as the Predominant mechanism for Resistance to Antibodies Targeting IGF-1R in Cells Derived from Childhood Sarcoma
    Authors: TJ Shacklefor, S Hariharan, AV Vaseva, K Alagoa, M Espinoza, HK Bid, F Li, H Zhong, DA Phelps, RD Roberts, H Cam, CA London, DC Guttridge, Y Chen, M Rao, Y Shiio, PJ Houghton
    Molecular Cancer Therapeutics, 2023-04-03;0(0):.  2023-04-03
  6. Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors
    Authors: R Tiedt, FJ King, C Stamm, MJ Niederst, S Delach, S Zumstein-M, J Meltzer, IJ Mulford, E Labrot, BS Engstler, S Baltschuka, G Kerr, J Golji, D Wyss, C Schnell, E Ainscow, JA Engelman, WR Sellers, J Barretina, G Caponigro, DG Porta
    Cell Reports, 2023-03-23;42(4):112297.  2023-03-23
  7. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
    Authors: W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin
    Nature Communications, 2023-03-22;14(1):1578.  2023-03-22
  8. The 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis
    Authors: F Nakashima, J Giménez-Ba, P Luis, S Presley, R Boer, M Chiusa, T Shibata, G Sulikowski, A Pozzi, C Schneider
    The Journal of Biological Chemistry, 2023-02-21;0(0):103050.  2023-02-21
  9. Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
    Authors: CH Chang, BJ Lin, CH Chen, NL Nguyen, TH Hsieh, JH Su, MC Chen
    Marine Drugs, 2023-01-21;21(2):.  2023-01-21
  10. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression
    Authors: ZS Lin, CC Chung, YC Liu, CH Chang, HC Liu, YY Liang, TL Huang, TM Chen, CH Lee, CH Tang, MC Hung, YH Chen
    Elife, 2023-01-09;12(0):.  2023-01-09
  11. Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K
    Authors: Chen, C;Wang, S;Yang, J;Huang, C;
    bioRxiv  2023-01-01
  12. Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer
    Authors: Lee, K;Lai, T;Lee, W;Chen, Y;Ho, K;Hung, W;Yang, Y;Chan, M;Hsieh, F;Chung, C;Chang, J;Chien, M;
    Cancers  2023-01-01
  13. Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
    Authors: SH Park, SJ Yoon, S Choi, J Jung, JY Park, YH Park, J Seo, J Lee, MS Lee, SJ Lee, MY Son, YL Cho, JS Kim, HJ Lee, J Jeong, DS Kim, YJ Park
    Experimental & Molecular Medicine, 2022-11-09;0(0):.  2022-11-09
  14. Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates Heparan Sulfate biosynthesis and shapes gastric cancer cell motility and invasion
    Authors: C Marques, J Poças, C Gomes, I Faria-Ramo, CA Reis, RR Vivès, A Magalhães
    The Journal of Biological Chemistry, 2022-09-28;0(0):102546.  2022-09-28
  15. Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors
    Authors: Y Kobayashi, GR Oxnard, EF Cohen, NR Mahadevan, JV Alessi, YP Hung, AA Bertram, DE Heppner, MF Ribeiro, KP Sacardo, R Saddi, MP Macedo, RB Blasco, J Li, KJ Kurppa, T Nguyen, E Voligny, G Ananda, R Chiarle, A Katz, MY Tolstoruko, LM Sholl, PA Jänne
    Nature Communications, 2022-09-24;13(1):5614.  2022-09-24
  16. Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells
    Authors: M Krchniakov, S Paukovceko, P Chlapek, J Neradil, J Skoda, R Veselska
    Frontiers in Pharmacology, 2022-09-07;13(0):976955.  2022-09-07
  17. Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer
    Authors: YF Wang, L Yu, ZL Hu, YF Fang, YY Shen, MF Song, Y Chen
    Cell Death & Disease, 2022-08-29;13(8):748.  2022-08-29
  18. Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
    Authors: SM Dieter, D Lovecchio, A Pataskar, MK Zowada, PR Körner, A Khalizieva, O van Tellin, D Jäger, H Glimm, R Agami
    Oncogene, 2022-07-07;0(0):.  2022-07-07
  19. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy
    Authors: MB Ryan, O Coker, A Sorokin, K Fella, H Barnes, E Wong, P Kanikarla, F Gao, Y Zhang, L Zhou, S Kopetz, RB Corcoran
    Cell Reports, 2022-06-21;39(12):110993.  2022-06-21
  20. EGFR inhibition reverses resistance to lenvatinib in hepatocellular carcinoma cells
    Authors: X He, Y Hikiba, Y Suzuki, Y Nakamori, Y Kanemaru, M Sugimori, T Sato, A Nozaki, M Chuma, S Maeda
    Scientific Reports, 2022-05-14;12(1):8007.  2022-05-14
  21. Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer
    Authors: AJ Weickhardt, DK Lau, M Hodgson-Ga, A Lavis, LJ Jenkins, N Vukelic, P Ioannidis, IY Luk, JM Mariadason
    BMC Cancer, 2022-05-02;22(1):478.  2022-05-02
  22. EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli
    Authors: S Song, Z Yu, Y You, C Liu, X Xie, H Lv, F Xiao, Q Zhu, C Qin
    Cell Death & Disease, 2022-04-15;13(4):351.  2022-04-15
  23. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
    Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
    Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28
  24. Different HSP90 Inhibitors Exert Divergent Effect on Myxoid Liposarcoma In Vitro and In Vivo
    Authors: C Vannas, L Andersson, S Dolatabadi, P Ranji, M Lindén, E Jonasson, A Ståhlberg, H Fagman, P Åman
    Biomedicines, 2022-03-07;10(3):.  2022-03-07
  25. Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis
    Authors: T Ueda, T Ito, M Inden, H Kurita, A Yamamoto, I Hozumi
    Frontiers in Pharmacology, 2022-02-03;13(0):805379.  2022-02-03
  26. Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
    Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
    Disease Models & Mechanisms, 2022-01-27;0(0):.  2022-01-27
  27. Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma
    Authors: L Scherschin, M Prem, I Kremenetsk, I Tinhofer, P Vajkoczy, AG Karbe, JS Onken
    International Journal of Molecular Sciences, 2022-01-17;23(2):.  2022-01-17
  28. Targeting SHP2 sensitizes differentiated thyroid carcinoma to the MEK inhibitor
    Authors: J Zhi, J Yi, X Hou, W Wang, W Yang, L Hu, J Huang, S Guo, X Ruan, M Gao, X Zheng
    American journal of cancer research, 2022-01-15;12(1):247-264.  2022-01-15
  29. IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma
    Authors: H Patel, R Mishra, N Yacoub, S Alanazi, MK Kilroy, JT Garrett
    Cancers, 2021-11-22;13(22):.  2021-11-22
  30. Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways
    Authors: TA Mannsåker, T Hoang, SN Aasen, OV Bjørnstad, H Parajuli, T Sundstrøm, FA Thorsen
    International Journal of Molecular Sciences, 2021-11-14;22(22):.  2021-11-14
  31. ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT)
    Authors: JD Choi, TJ Kim, BC Jeong, HG Jeon, SS Jeon, MY Kang, SY Yeom, SI Seo
    Scientific Reports, 2021-11-09;11(1):21984.  2021-11-09
  32. Three newly established immortalized mesothelial cell lines exhibit morphological phenotypes corresponding to malignant mesothelioma epithelioid, intermediate, and sarcomatoid types, respectively
    Authors: T Sato, H Nakanishi, K Akao, M Okuda, S Mukai, T Kiyono, Y Sekido
    Cancer Cell International, 2021-10-18;21(1):546.  2021-10-18
  33. Characterization of receptor tyrosine kinase activation and biological activity of toceranib phosphate in canine urothelial carcinoma cell lines
    Authors: DI Korec, DS Louke, JT Breitbach, JA Geisler, BD Husbands, JM Fenger
    Bmc Veterinary Research, 2021-10-02;17(1):320.  2021-10-02
  34. Oral submucous fibrosis stimulates invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by activating MMP-2 and IGF-IR
    Authors: PN Chen, CW Lin, SF Yang, YC Chang
    Journal of Cellular and Molecular Medicine, 2021-09-15;0(0):.  2021-09-15
  35. NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck
    Authors: YP Wang, IJ Liu, KC Chen, HC Wu
    Oncogenesis, 2021-08-31;10(8):59.  2021-08-31
  36. Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression
    Authors: SJ Oh, KH Noh, KH Song, TW Kim
    International Journal of Molecular Sciences, 2021-08-17;22(16):.  2021-08-17
  37. Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration
    Authors: P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk
    Theranostics, 2021-07-25;11(17):8430-8447.  2021-07-25
  38. Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation
    Authors: AC Harttrampf, MEM da Costa, A Renoult, E Daudigeos-, B Geoerger
    BMC Cancer, 2021-07-20;21(1):833.  2021-07-20
  39. New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling
    Authors: M Mahdal, J Neradil, P Mudry, S Paukovceko, I Staniczkov, J Urban, P Macsek, L Pazourek, T Tomas, R Veselska
    Cancers, 2021-07-15;13(14):.  2021-07-15
  40. Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1alpha/TGF-alpha expression
    Authors: K Nishii, K Ohashi, H Watanabe, G Makimoto, T Nakasuka, H Higo, K Ninomiya, Y Kato, T Kubo, K Rai, E Ichihara, K Hotta, M Tabata, Y Maeda, K Kiura
    Oncology Letters, 2021-07-07;22(3):639.  2021-07-07
  41. Identification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells
    Authors: J Lee, R Chen, T Mohanakuma, R Bremner, S Mittal, TP Fleming
    OncoTargets and Therapy, 2021-06-21;14(0):3813-3820.  2021-06-21
  42. Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling
    Authors: SJ Lee, KM Choi, G Bang, SG Park, EB Kim, JW Choi, YH Chung, J Kim, SG Lee, E Kim, JY Kim
    Cancers, 2021-06-07;13(11):.  2021-06-07
  43. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
    Authors: HH Lee, YN Wang, WH Yang, W Xia, Y Wei, LC Chan, YH Wang, Z Jiang, S Xu, J Yao, Y Qiu, YH Hsu, WL Hwang, M Yan, JH Cha, JL Hsu, J Shen, Y Ye, X Wu, MF Hou, LM Tseng, SC Wang, MR Pan, CH Yang, YL Wang, H Yamaguchi, D Pang, GN Hortobagyi, D Yu, MC Hung
    Nature Communications, 2021-05-13;12(1):2788.  2021-05-13
  44. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells
    Authors: S Hafner, M Schmiech, SJ Lang
    Frontiers in Pharmacology, 2021-05-05;12(0):611657.  2021-05-05
  45. LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance
    Authors: O Billing, Y Holmgren, D Nosek, H Hedman, O Hemmingsso
    Oncogene, 2021-05-04;0(0):.  2021-05-04
  46. DNA damage response- and JAK-dependent regulation of PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells exposed to 5-fluorouracil (5-FU)
    Authors: C Lailler, M Lamuraglia, F Racine, C Louandre, C Godin, B Chauffert, A Galmiche, Z Saidak
    Translational Oncology, 2021-05-02;14(8):101110.  2021-05-02
  47. Galectin?9 suppresses the tumor growth of colon cancer in�vitro and in�vivo
    Authors: A Morishita, K Nomura, J Tani, K Fujita, H Iwama, K Takuma, M Nakahara, T Tadokoro, K Oura, T Chiyo, S Fujihara, T Niki, M Hirashima, A Nishiyama, T Himoto, T Masaki
    Oncology reports, 2021-04-28;45(6):.  2021-04-28
  48. Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells
    Authors: N Singh, NV Frey, B Engels, DM Barrett, O Shestova, P Ravikumar, KD Cummins, YG Lee, R Pajarillo, I Chun, A Shyu, SL Highfill, A Price, L Zhao, L Peng, B Granda, M Ramones, XM Lu, DA Christian, J Perazzelli, SF Lacey, NH Roy, JK Burkhardt, F Colomb, M Damra, M Abdel-Mohs, T Liu, D Liu, DM Standley, RM Young, JL Brogdon, SA Grupp, CH June, SL Maude, S Gill, M Ruella
    Nature Medicine, 2021-04-22;0(0):.  2021-04-22
  49. Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells
    Authors: J Tsui, S Qi, S Perrino, M Leibovitch, P Brodt
    Biomolecules, 2021-04-01;11(4):.  2021-04-01
  50. Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration
    Authors: P Zhang, X Liu, P Guo, X Li, Z He, Z Li, MJ Stoddart, S Grad, W Tian, D Chen, X Zou, Z Zhou, S Liu
    Bioactive materials, 2021-03-09;6(10):3097-3108.  2021-03-09
  51. Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations
    Authors: B Royer-Poko, MA Busch, S Tenbusch, M Schmidt, M Beier, AD Woods, H Thiele, J Mora
    Cancers, 2020-12-28;13(1):.  2020-12-28
  52. HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma
    Authors: L Hüser, MM Kokkalenio, K Granados, J Dworacek, A Federico, M Vierthaler, D Novak, I Arkhypov, T Hielscher, V Umansky, P Altevogt, J Utikal
    Cancers, 2020-12-14;12(12):.  2020-12-14
  53. Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines
    Authors: M Fuentes-Ba, MP Ventero, JA Encinar, P García-Mor, M Poveda-Del, E Pérez-Vale, VM Barberá, J Gallego-Pl, Á Rodríguez-, J Martín-Nie, M Saceda
    Cancers, 2020-12-11;12(12):.  2020-12-11
  54. ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
    Authors: S Pietrobono, G Anichini, C Sala, F Manetti, LL Almada, S Pepe, RM Carr, BD Paradise, JN Sarkaria, JI Davila, L Tofani, I Battisti, G Arrigoni, L Ying, C Zhang, H Li, A Meves, ME Fernandez-, B Stecca
    Nat Commun, 2020-11-17;11(1):5865.  2020-11-17
  55. Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma
    Authors: Z Areeb, SF Stuart, AJ West, J Gomez, HPT Nguyen, L Paradiso, A Zulkifli, J Jones, AH Kaye, AP Morokoff, RB Luwor
    Sci Rep, 2020-10-20;10(1):17768.  2020-10-20
  56. Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling
    Authors: B Zhou, J Liu, L Zeng, S Zhu, H Wang, TR Billiar, G Kroemer, DJ Klionsky, HJ Zeh, J Jiang, D Tang, R Kang
    Nat Microbiol, 2020-10-19;0(0):.  2020-10-19
  57. Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1
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  213. Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.
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  223. Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.
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  224. The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.
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  225. Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin).
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  236. Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells.
    Authors: Yoon YK, Kim HP, Han SW, Hur HS, Oh do Y, Im SA, Bang YJ, Kim TY
    Mol. Cancer Ther., 2009-09-15;8(9):2526-36.  2009-09-15
  237. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines.
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    J. Cell Biol., 2009-05-11;185(4):743-54.  2009-05-11
  240. Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.
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    Carcinogenesis, 2009-04-20;30(7):1097-105.  2009-04-20
  241. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells.
    Authors: Eckstein N, Servan K, Hildebrandt B, Politz A, von Jonquieres G, Wolf-Kummeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Beier M, Dietel M, Royer-Pokora B, Denkert C, Royer HD
    Cancer Res., 2009-03-24;69(7):2996-3003.  2009-03-24
  242. Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.
    Authors: Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, Tanaka A, Kusano E
    Kidney Int., 2009-02-25;75(11):1173-83.  2009-02-25
  243. Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells.
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    Br. J. Cancer, 2009-02-24;100(6):941-9.  2009-02-24
  244. A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells.
    Authors: Kashiwagi K, Virgona N, Harada K, Kido W, Yano Y, Ando A, Hagiwara K, Yano T
    Life Sci., 2009-02-14;84(19):650-6.  2009-02-14
  245. Response to sunitinib malate in advanced alveolar soft part sarcoma.
    Authors: Stacchiotti S, Tamborini E, Marrari A, Brich S, Rota SA, Orsenigo M, Crippa F, Morosi C, Gronchi A, Pierotti MA, Casali PG, Pilotti S
    Clin. Cancer Res., 2009-02-01;15(3):1096-104.  2009-02-01
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  248. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
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  249. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.
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  1. What are the phosphorylation site(s) of the 49 different tyrosine residues on the RTKs?

    • This kit uses a pan anti-phospho-tyrosine antibody as the detection antibody, which means it is capable of detecting phosphorylation at any available tyrosine. It is not designed to be specific for one phosphorylation site on each molecule. For instance, PDGF R alpha has multiple sites of tyrosine phosphorylation (see the “PTM/Processing” section of for a list of the currently identified sites). 

  2. Can the Human Phospho-RTK Array be used for measuring the relative levels of total RTKs present in a sample?

    • No. Although the array kit uses capture antibodies that recognize both phosphorylated and unphosphorylated RTKs, the detection antibody is a pan anti-phospho-tyrosine antibody which only detects phosphorylated tyrosines on activated RTKs.

  3. To confirm positive signal for an RTK by IP-Western blot, are the capture antibodies from the Human Phospho-RTK Array Kit offered separately?

    • The identities of the capture antibodies on the Human Phospho-RTK Array are considered proprietary. However, to help investigators confirm their array results, Bio-Techne offers antibodies for each RTK detectable in the array kit. These antibodies are validated for Western blot and can be found in our catalog. A pan anti-phospho-tyrosine-HRP detection antibody is also available (Catalog # HAM1676).

View all Proteome Profiler Antibody Array FAQs

Reviews for Proteome Profiler Human Phospho-RTK Array Kit

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Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 10/31/2023

The reagent kit testing remains as sensitive and stable as ever. We have repeated it multiple times in tissue samples, and the results are reliable.

Proteome Profiler Human Phospho-RTK Array Kit
By 帆 张 on 08/31/2021

Great, excellent, can't wait to start my experiences right away.

Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 07/15/2021

Purchased to screen changes induced by RTK inhibitors of cancer cell lines. Easy protocol, good clear results which could be independently validated by western blot. The only issue is that R&D are unable to supply information regarding the phospho-site detected, the antibody used in the array or the receptor chain recognised, so you just have to make an educated guess as to which antibody is most appropriate for an independent validation by western blotting etc. Excellent as an initial screen though.

Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 11/18/2019

I would recommend to my colleagues, nicely performed. (for image acquiring, I used ImageQuant LAS 4000)

Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 03/13/2019

Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 10/29/2018

Proteome Profiler Human Phospho-RTK Array Kit
By Jiawan Wang on 08/28/2018

The kit is excellent for p-RTK array in human cell lines. I recommended it to my colleague.

Proteome Profiler Human Phospho-RTK Array Kit
By Adam Guess on 10/20/2017