89 results for "c-Abl" in 产品
c-Abl Products
c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; ...
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
Highly potent pan-Src/Bcr-Abl inhibitor
| Alternate Names: | BMS-354825 |
| Chemical Name: | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide |
| Purity: | ≥98% |
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Alternate Names: | Gleevec,CGP 57148B |
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #8E9 |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: c-Abl Antibody (8E9) [NBP2-49695]](https://resources.rndsystems.com/images/products/c-Abl-Antibody-8E9-Western-Blot-NBP2-49695-img0004.jpg "Western Blot: c-Abl Antibody (8E9) [NBP2-49695]")
Dual Src-Abl inhibitor; antiproliferative
| Alternate Names: | SKI-606 |
| Chemical Name: | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: c-Abl Antibody [NBP2-15631]](https://resources.rndsystems.com/images/products/c-Abl-Antibody-Western-Blot-NBP2-15631-img0009.jpg "Western Blot: c-Abl Antibody [NBP2-15631]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]](https://resources.rndsystems.com/images/products/c-Abl-[p-Tyr245]-Antibody-Western-Blot-NBP3-13326-img0003.jpg "Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]")
| Reactivity: | Human |
| Source: | E. coli |
| Accession #: | P00519.4 |
| Applications: | Enzyme Activity |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90289]](https://resources.rndsystems.com/images/products/c-Abl-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-90289-img0006.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90289]")
Potent, selective Src family kinase inhibitor
| Chemical Name: | 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% |
Src family kinase inhibitor; also inhibits c-Abl
| Alternate Names: | 1-NA-PP 1 |
| Chemical Name: | 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% |
Potent multi-kinase and pan-Bcr-Abl inhibitor
| Alternate Names: | Ponatinib |
| Chemical Name: | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide |
| Purity: | ≥98% |
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
| Chemical Name: | 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide |
| Purity: | ≥98% |
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
| Chemical Name: | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide |
| Purity: | ≥98% |
Potent EGFR and VEGFR inhibitor
| Chemical Name: | 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Purity: | ≥98% |
Ras signaling inhibitor; inhibits Ack1 and GCK
| Chemical Name: | N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| Purity: | ≥98% |
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable
| Alternate Names: | AZD 0530 |
| Chemical Name: | N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine |
| Purity: | ≥98% |
BCR-ABL1 kinase PROTAC® Degrader
| Chemical Name: | (2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![c-Abl Antibody - BSA Free Immunocytochemistry/ Immunofluorescence: c-Abl Antibody - BSA Free [NBP1-90287]](https://resources.rndsystems.com/images/products/nbp1-90287_rabbit-polyclonal-c-abl-antibody-305202510183413.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody - BSA Free [NBP1-90287]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ELISA, ICC/IF |
![Immunohistochemistry-Paraffin: c-Abl Antibody [NBP2-99737]](https://resources.rndsystems.com/images/products/c-Abl-Antibody-Immunohistochemistry-Paraffin-NBP2-99737-img0002.jpg "Immunohistochemistry-Paraffin: c-Abl Antibody [NBP2-99737]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #M209 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![c-Abl [p Tyr412] Antibody](https://resources.rndsystems.com/images/products/nbp3-23318_rabbit-c-abl-p-tyr412-pab-19920231915414.jpg "Western Blot: c-Abl [p Tyr412] Antibody [NBP3-23318] -")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: c-Abl Antibody [NBP1-90288]](https://resources.rndsystems.com/images/products/c-Abl-Antibody-Immunohistochemistry-NBP1-90288-img0004.jpg "Immunohistochemistry-Paraffin: c-Abl Antibody [NBP1-90288]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![c-Abl [p Tyr245] Antibody](https://resources.rndsystems.com/images/products/nbp3-23313_rabbit-c-abl-p-tyr245-pab-199202312523642.jpg "Western Blot: c-Abl [p Tyr245] Antibody [NBP3-23313] -")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
