Saracatinib
Tocris Bioscience | Catalog # 7189
Key Product Details
Description
Alternative Names
Product Description
Saracatinib is a potent and selective Src tyrosine kinase family inhibitor (IC50 = 4-10 nM). Inhibits Src, c-Yes, Fyn, Lyn, Blk, Fgr, and Lck. Exhibits selectivity over other tyrosine kinases (IC50 values are 30, 66 and 200 nM for v-Abl, EGFR and c-Kit, respectively). Suppresses invasion of HT1080 cells through a collagen matrix and inhibits metastasis in a murine model of bladder cancer. Inhibits the growth of prostate cancer cell lines. Also suppresses MERS-CoV replication at the early stage of replication (EC50 = 2.9 μM) and displays broad-spectrum activity against other human coronaviruses. Also blocks dengue virus RNA replication. Reverses memory deficit in a mouse AD model and rescues synapse density. Inhibits osteoclast activity, resorption and formation. Induces autophagy. Orally bioavailable.
Product Specifications for Saracatinib
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.84 | 20 | |
| Ethanol | 54.2 | 100 |
Preparing Stock Solutions for Saracatinib
The following data is based on the product molecular weight 542.03.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.84 mL | 9.22 mL | 18.45 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.
- Kaufman Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann.Neurol. 2015 PMID: 25707991
- Green Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Mol.Oncol. 2009 PMID: 19393585
- De Wispelaere The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J.Virol. 2013 PMID: 23616652
- Hennequin N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J.Med.Chem. 2006 PMID: 17064066
Product Documents for Saracatinib
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Saracatinib
For research use only
Related Research Areas
Citations for Saracatinib
Powered by Bioz
Customer Reviews for Saracatinib (1)
Have you used Saracatinib?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review
Customer Images
-
Species: HumanAssay Type: In VitroVerified Customer | Posted 08/19/2024A curve of Saracatinib was performed at different concentrations to standardize the working concentration for future assays at a specific incubation time established in our cell line. This was done by detecting the change in phosphorylated SRC levels compared to total SRC levels using western blot.
There are no reviews that match your criteria.